microRNAs: Fad or future of liver disease

被引：63

作者：

Lakner, Ashley M. ^{[2
]}

Bonkovsky, Herbert L. ^{[1
,2
,3
,4
,5
,6
]}

Schrum, Laura W. ^{[1
,2
,3
]}

机构：

[1] Carolinas Med Ctr, Liver Digest & Metab Disorders Lab, Charlotte, NC 28203 USA

[2] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA

[3] Carolinas Med Ctr, Liver Biliary Pancreat Ctr, Charlotte, NC 28203 USA

[4] Univ N Carolina, Dept Med, Chapel Hill, NC 27514 USA

[5] Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA

[6] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06030 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 20期

关键词：

Liver; Fibrosis; microRNA; mRNA; Hepatic stellate cells; HEPATITIS-C VIRUS; NONALCOHOLIC STEATOHEPATITIS; DIFFERENTIAL EXPRESSION; PROFILING REVEALS; STELLATE CELLS; IDENTIFICATION; GENE; REGENERATION; MODULATION; MECHANISMS;

D O I：

10.3748/wjg.v17.i20.2536

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. (C) 2011 Baishideng. All rights reserved.

引用

页码：2536 / 2542

页数：7

共 54 条

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