Dysregulated Metabolic Pathways in Subjects with Obesity and Metabolic Syndrome

被引:17
作者
Mir, Fayaz Ahmad [1 ]
Ullah, Ehsan [2 ]
Mall, Raghvendra [2 ,3 ]
Iskandarani, Ahmad [1 ]
Samra, Tareq A. [1 ]
Cyprian, Farhan [4 ]
Parray, Aijaz [5 ]
Alkasem, Meis [1 ]
Abdalhakam, Ibrahem [1 ]
Farooq, Faisal [2 ]
Abou-Samra, Abdul-Badi [1 ]
机构
[1] Hamad Med Corp, Acad Hlth Syst, Qatar Metab Inst, Doha, Qatar
[2] Hamad Bin Khalifa Univ, Qatar Comp Res Inst QCRI, Doha, Qatar
[3] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38104 USA
[4] Qatar Univ, Coll Med, QU Hlth, Doha, Qatar
[5] Hamad Med Corp, Acad Hlth Syst, Qatar Neurosci Inst, Doha, Qatar
关键词
metabolomics; obesity; metabolic syndrome; inflammation; sphingomyelins; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; MORTALITY; PLASMA; RISK;
D O I
10.3390/ijms23179821
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Obesity coexists with variable features of metabolic syndrome, which is associated with dysregulated metabolic pathways. We assessed potential associations between serum metabolites and features of metabolic syndrome in Arabic subjects with obesity. Methods: We analyzed a dataset of 39 subjects with obesity only (OBO, n = 18) age-matched to subjects with obesity and metabolic syndrome (OBM, n = 21). We measured 1069 serum metabolites and correlated them to clinical features. Results: A total of 83 metabolites, mostly lipids, were significantly different (p < 0.05) between the two groups. Among lipids, 22 sphingomyelins were decreased in OBM compared to OBO. Among non-lipids, quinolinate, kynurenine, and tryptophan were also decreased in OBM compared to OBO. Sphingomyelin is negatively correlated with glucose, HbA1C, insulin, and triglycerides but positively correlated with HDL, LDL, and cholesterol. Differentially enriched pathways include lysine degradation, amino sugar and nucleotide sugar metabolism, arginine and proline metabolism, fructose and mannose metabolism, and galactose metabolism. Conclusions: Metabolites and pathways associated with chronic inflammation are differentially expressed in subjects with obesity and metabolic syndrome compared to subjects with obesity but without the clinical features of metabolic syndrome.
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页数:13
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