Systems biology of polycystic kidney disease: a critical review

被引：16

作者：

Menezes, Luis Fernando ^{[1
]}

Germino, Gregory G. ^{[1
,2
]}

机构：

[1] NIDDK, Kidney Dis Branch, NIH, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2015年 / 7卷 / 01期

关键词：

CYST FORMATION; GENES; MODEL; IDENTIFICATION; EXPRESSION; PATHWAYS; CELLS; CILIA; PHOSPHORYLATION; PROLIFERATION;

D O I：

10.1002/wsbm.1289

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The proliferation and diminishing costs of 'omics' approaches have finally opened the doors for small and medium laboratories to enter the 'systems biology era'. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the 'cyst-ems biology' of polycystic kidney disease. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

引用

页码：39 / 52

页数：14

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