Systems biology of polycystic kidney disease: a critical review

被引：16
|
作者：
Menezes, Luis Fernando [1 ]
Germino, Gregory G. [1 ,2 ]
机构：
[1] NIDDK, Kidney Dis Branch, NIH, Bethesda, MD 20892 USA
[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2015年 / 7卷 / 01期
关键词：
CYST FORMATION; GENES; MODEL; IDENTIFICATION; EXPRESSION; PATHWAYS; CELLS; CILIA; PHOSPHORYLATION; PROLIFERATION;
D O I：
10.1002/wsbm.1289
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The proliferation and diminishing costs of 'omics' approaches have finally opened the doors for small and medium laboratories to enter the 'systems biology era'. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the 'cyst-ems biology' of polycystic kidney disease. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
引用
收藏
页码：39 / 52
页数：14
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