A novel and efficient synthesis of tocopheryl quinones by homogeneous and heterogeneous methyltrioxorhenium/hydrogen peroxide catalytic systems

被引：24

作者：

Saladino, Raffaele ^{[1
]}

Neri, Veronica ^{[1
]}

Farina, Angela ^{[1
]}

Crestini, Claudia ^{[2
]}

Nencioni, Lucia ^{[3
]}

Palamara, Anna Teresa ^{[3
]}

机构：

[1] Univ Tuscia, Dipartimento Agrobiol & Agrochim, I-01100 Viterbo, Italy

[2] Univ Tor Vergata, Dipartimento Sci & Technol Chim, I-00185 Rome, Italy

[3] Univ Roma La Sapienza, Sez Microbiol Framaceut, Dipartimento Sci Salute Pubbl, I-00185 Rome, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 02期

关键词：

antiviral agents; heterogeneous catalysis; homogeneous catalysis; hydrogen peroxide; quinones; rhenium;

D O I：

10.1002/adsc.200700340

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A convenient and efficient application of heterogeneous poly(4-vinylpyridine), poly(4-vinylpyridine N-oxide), and polystyrene/methylrhenium trioxide systems for the selective oxidation of tocopherols and tocopherol derivatives to the corresponding ortho- and para-tocopherylquinones is described. Environment friendly, easily available, and low-cost hydrogen peroxide (H2O2) was used as the oxygen atom donor. The antiviral activity of the newly synthesized tocopherylquinones and their parent tocopherols against influenza A virus is also reported. On the basis of the biological assay, the activity of tocopherols against influenza virus is higher than that showed by the corresponding tocopheryl-quinones, thus suggesting, for the first time, a drawback effect of the oxidative metabolism on the antiviral activity of these compounds.

引用

页码：321 / 331

页数：11

共 88 条

[1] OXIDATION OF METHOXYBENZENES TO P-BENZOQUINONES CATALYZED BY METHYLTRIOXORHENIUM(VII) [J].