Neurotrophins and their role in pathogenesis of alopecia areata

Neurotrophins comprise a family of structurally and functionally related proteins that are critical for the development and maintenance of cutaneous innervation. They also fulfill multiple non-neurotrophic functions in skin, including regulation of epidermal proliferation and apoptosis, control of hair follicle development and cycling, and melanogenesis. Numerous indications suggest that neurotrophins play an important role in the pathogenesis of a variety of autoimmune diseases. In this review, we focus on the role of neurotrophins in the pathogenesis of alopecia areata, an autoimmune disorder that affects actively growing hair follicles. Recent data suggest that neurotrophins and their receptors are differentially expressed among the subsets of immune cells in alopecia areata-affected skin. Experimental data suggest that neurotrophins may regulate both the cyclic activity of the hair follicle and the functions of immune cells of inflammatory infiltrates. Additional research is required to bridge the gap between our current knowledge of neurotrophin functions in skin affected by alopecia areata and our knowledge of their potential clinical applications. Progress in this area of research will hopefully lead to the development of multiple applications for neurotrophins and their agonists/antagonists in alopecia areata and other hair growth disorders.