Shared genetic background between children and adults with attention deficit/hyperactivity disorder

被引：65

作者：

Rovira, Paula ^{[1
,2
]}

Demontis, Ditte ^{[3
,4
,5
,6
]}

Sanchez-Mora, Cristina ^{[1
,2
,7
,8
]}

Zayats, Tetyana ^{[9
,10
,11
,12
]}

Klein, Marieke ^{[13
,14
]}

Mota, Nina Roth ^{[13
,15
,16
]}

Weber, Heike ^{[17
,18
]}

Garcia-Martinez, Iris ^{[1
,2
,19
,20
]}

Pagerols, Mireia ^{[1
,2
]}

Vilar-Ribo, Laura ^{[1
,2
]}

Arribas, Lorena ^{[1
,2
]}

Richarte, Vanesa ^{[2
,7
,21
]}

Corrales, Montserrat ^{[2
,7
,21
]}

Fadeuilhe, Christian ^{[2
,7
,21
]}

Bosch, Rosa ^{[2
,7
,21
]}

Martin, Gemma Espanol ^{[2
,7
,22
]}

Almos, Peter ^{[23
]}

Doyle, Alysa E. ^{[24
,25
]}

Grevet, Eugenio Horacio ^{[15
,26
]}

Grimm, Oliver ^{[18
]}

Halmoy, Anne ^{[9
,27
]}

Hoogman, Martine ^{[13
]}

Hutz, Mara ^{[28
]}

Jacob, Christian P. ^{[23
]}

Kittel-Schneider, Sarah ^{[18
]}

Knappskog, Per M. ^{[29
,30
]}

Lundervold, Astri J. ^{[31
]}

Rivero, Olga ^{[23
]}

Rovaris, Diego Luiz ^{[15
,28
,32
]}

Salatino-Oliveira, Angelica ^{[28
]}

da Silva, Bruna Santos ^{[15
,28
]}

Svirin, Evgeniy ^{[23
,33
]}

Sprooten, Emma ^{[34
]}

Strekalova, Tatyana ^{[23
,33
,35
]}

Arias-Vasquez, Alejandro ^{[13
,16
]}

Sonuga-Barke, Edmund J. S. ^{[36
,37
]}

Asherson, Philip ^{[38
]}

Bau, Claiton Henrique Dotto ^{[15
,28
]}

Buitelaar, Jan K. ^{[34
,39
]}

Cormand, Bru ^{[8
,40
,41
,42
]}

Faraone, Stephen V. ^{[43
,44
]}

Haavik, Jan ^{[9
,27
]}

Johansson, Stefan E. ^{[29
,30
]}

Kuntsi, Jonna ^{[38
]}

Larsson, Henrik ^{[45
,46
]}

Lesch, Klaus-Peter ^{[23
,33
,35
]}

Reif, Andreas ^{[18
]}

Rohde, Luis Augusto ^{[47
]}

Casas, Miquel ^{[1
,2
,7
,21
]}

Borglum, Anders D. ^{[3
,4
,5
,6
]}

机构：

[1] Univ Autonoma Barcelona, VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Catalonia, Spain

[2] Hosp Univ Vall Hebron, Dept Psychiat, Barcelona, Catalonia, Spain

[3] Aarhus Univ, Dept Biomed Human Genet, Aarhus, Denmark

[4] Aarhus Univ, Ctr Integrat Sequencing, ISEQ, Aarhus, Denmark

[5] IPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[6] Ctr Genom & Personalized Med, Aarhus, Denmark

[7] Inst Salud Carlos III, Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain

[8] Univ Barcelona, Dept Genet Microbiol & Stat, Fac Biol, Barcelona, Spain

[9] Univ Bergen, Dept Biomed, Bergen, Norway

[10] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[11] Harvard Med Sch, Boston, MA 02115 USA

[12] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[13] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Human Genet, Nijmegen, Netherlands

[14] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands

[15] Hosp Clin Porto Alegre, Adult Div, ADHD Outpatient Program, Porto Alegre, RS, Brazil

[16] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands

[17] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[18] Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

[19] BST, Barcelona, Spain

[20] Univ Autonoma Barcelona VHIR UAB, Vall Hebron Inst Recerca, Grp Med Transfus, Barcelona, Spain

[21] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Catalonia, Spain

[22] VHIR, Grp Psychiat Mental Hlth & Addict, Barcelona, Catalonia, Spain

[23] Univ Wurzburg, Ctr Mental Hlth, Div Mol Psychiat, Wurzburg, Germany

[24] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA

[25] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[26] Univ Fed Rio Grande do Sul, Fac Med, Dept Psychiat, Porto Alegre, RS, Brazil

[27] Haukeland Hosp, Div Psychiat, Bergen, Norway

[28] Univ Fed Rio Grande do Sul, Inst Biosci, Dept Genet, Porto Alegre, RS, Brazil

[29] Haukeland Hosp, Ctr Med Genet & Mol Med, Bergen, Norway

[30] Univ Bergen, Dept Clin Sci, Bergen, Norway

[31] Univ Bergen, Dept Biol & Med Psychol, Bergen, Norway

[32] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil

[33] IM Sechenov First Moscow State Med Univ, Inst Mol Med, Lab Psychiat Neurobiol, Moscow, Russia

[34] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands

[35] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Neurosci, Maastricht, Netherlands

[36] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[37] Aarhus Univ, Dept Child & Adolescent Psychiat, Aarhus, Denmark

[38] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat, London, England

[39] Karakter Child & Adolescent Psychiat, Nijmegen, Netherlands

[40] IBUB, Barcelona, Catalonia, Spain

[41] CIBERER, Barcelona, Spain

[42] IRSJD, Esplugas de Llobregat, Catalonia, Spain

[43] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA

[44] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

[45] Orebro Univ, Sch Med Sci, Orebro, Sweden

[46] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[47] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Child Psychiat, Porto Alegre, RS, Brazil

来源：

NEUROPSYCHOPHARMACOLOGY | 2020年 / 45卷 / 10期

基金：

美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

GENOME-WIDE ASSOCIATION; DEFICIT HYPERACTIVITY DISORDER; CA2+-DEPENDENT ACTIVATOR PROTEIN; LD SCORE REGRESSION; SECRETION; ADHD; HERITABILITY; CHILDHOOD; SYMPTOMS; METAANALYSIS;

D O I：

10.1038/s41386-020-0664-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

引用

页码：1617 / 1626

页数：10

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