Shared genetic background between children and adults with attention deficit/hyperactivity disorder

被引：65

作者：

Rovira, Paula ^{[1
,2
]}

Demontis, Ditte ^{[3
,4
,5
,6
]}

Sanchez-Mora, Cristina ^{[1
,2
,7
,8
]}

Zayats, Tetyana ^{[9
,10
,11
,12
]}

Klein, Marieke ^{[13
,14
]}

Mota, Nina Roth ^{[13
,15
,16
]}

Weber, Heike ^{[17
,18
]}

Garcia-Martinez, Iris ^{[1
,2
,19
,20
]}

Pagerols, Mireia ^{[1
,2
]}

Vilar-Ribo, Laura ^{[1
,2
]}

Arribas, Lorena ^{[1
,2
]}

Richarte, Vanesa ^{[2
,7
,21
]}

Corrales, Montserrat ^{[2
,7
,21
]}

Fadeuilhe, Christian ^{[2
,7
,21
]}

Bosch, Rosa ^{[2
,7
,21
]}

Martin, Gemma Espanol ^{[2
,7
,22
]}

Almos, Peter ^{[23
]}

Doyle, Alysa E. ^{[24
,25
]}

Grevet, Eugenio Horacio ^{[15
,26
]}

Grimm, Oliver ^{[18
]}

Halmoy, Anne ^{[9
,27
]}

Hoogman, Martine ^{[13
]}

Hutz, Mara ^{[28
]}

Jacob, Christian P. ^{[23
]}

Kittel-Schneider, Sarah ^{[18
]}

Knappskog, Per M. ^{[29
,30
]}

Lundervold, Astri J. ^{[31
]}

Rivero, Olga ^{[23
]}

Rovaris, Diego Luiz ^{[15
,28
,32
]}

Salatino-Oliveira, Angelica ^{[28
]}

da Silva, Bruna Santos ^{[15
,28
]}

Svirin, Evgeniy ^{[23
,33
]}

Sprooten, Emma ^{[34
]}

Strekalova, Tatyana ^{[23
,33
,35
]}

Arias-Vasquez, Alejandro ^{[13
,16
]}

Sonuga-Barke, Edmund J. S. ^{[36
,37
]}

Asherson, Philip ^{[38
]}

Bau, Claiton Henrique Dotto ^{[15
,28
]}

Buitelaar, Jan K. ^{[34
,39
]}

Cormand, Bru ^{[8
,40
,41
,42
]}

Faraone, Stephen V. ^{[43
,44
]}

Haavik, Jan ^{[9
,27
]}

Johansson, Stefan E. ^{[29
,30
]}

Kuntsi, Jonna ^{[38
]}

Larsson, Henrik ^{[45
,46
]}

Lesch, Klaus-Peter ^{[23
,33
,35
]}

Reif, Andreas ^{[18
]}

Rohde, Luis Augusto ^{[47
]}

Casas, Miquel ^{[1
,2
,7
,21
]}

Borglum, Anders D. ^{[3
,4
,5
,6
]}

机构：

[1] Univ Autonoma Barcelona, VHIR, Grp Psychiat Mental Hlth & Addict, Psychiat Genet Unit, Barcelona, Catalonia, Spain

[2] Hosp Univ Vall Hebron, Dept Psychiat, Barcelona, Catalonia, Spain

[3] Aarhus Univ, Dept Biomed Human Genet, Aarhus, Denmark

[4] Aarhus Univ, Ctr Integrat Sequencing, ISEQ, Aarhus, Denmark

[5] IPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark

[6] Ctr Genom & Personalized Med, Aarhus, Denmark

[7] Inst Salud Carlos III, Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain

[8] Univ Barcelona, Dept Genet Microbiol & Stat, Fac Biol, Barcelona, Spain

[9] Univ Bergen, Dept Biomed, Bergen, Norway

[10] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[11] Harvard Med Sch, Boston, MA 02115 USA

[12] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA

[13] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Human Genet, Nijmegen, Netherlands

[14] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands

[15] Hosp Clin Porto Alegre, Adult Div, ADHD Outpatient Program, Porto Alegre, RS, Brazil

[16] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands

[17] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[18] Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

[19] BST, Barcelona, Spain

[20] Univ Autonoma Barcelona VHIR UAB, Vall Hebron Inst Recerca, Grp Med Transfus, Barcelona, Spain

[21] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Catalonia, Spain

[22] VHIR, Grp Psychiat Mental Hlth & Addict, Barcelona, Catalonia, Spain

[23] Univ Wurzburg, Ctr Mental Hlth, Div Mol Psychiat, Wurzburg, Germany

[24] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA

[25] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[26] Univ Fed Rio Grande do Sul, Fac Med, Dept Psychiat, Porto Alegre, RS, Brazil

[27] Haukeland Hosp, Div Psychiat, Bergen, Norway

[28] Univ Fed Rio Grande do Sul, Inst Biosci, Dept Genet, Porto Alegre, RS, Brazil

[29] Haukeland Hosp, Ctr Med Genet & Mol Med, Bergen, Norway

[30] Univ Bergen, Dept Clin Sci, Bergen, Norway

[31] Univ Bergen, Dept Biol & Med Psychol, Bergen, Norway

[32] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil

[33] IM Sechenov First Moscow State Med Univ, Inst Mol Med, Lab Psychiat Neurobiol, Moscow, Russia

[34] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands

[35] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Neurosci, Maastricht, Netherlands

[36] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[37] Aarhus Univ, Dept Child & Adolescent Psychiat, Aarhus, Denmark

[38] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat, London, England

[39] Karakter Child & Adolescent Psychiat, Nijmegen, Netherlands

[40] IBUB, Barcelona, Catalonia, Spain

[41] CIBERER, Barcelona, Spain

[42] IRSJD, Esplugas de Llobregat, Catalonia, Spain

[43] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA

[44] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA

[45] Orebro Univ, Sch Med Sci, Orebro, Sweden

[46] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[47] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Child Psychiat, Porto Alegre, RS, Brazil

来源：

NEUROPSYCHOPHARMACOLOGY | 2020年 / 45卷 / 10期

基金：

美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

GENOME-WIDE ASSOCIATION; DEFICIT HYPERACTIVITY DISORDER; CA2+-DEPENDENT ACTIVATOR PROTEIN; LD SCORE REGRESSION; SECRETION; ADHD; HERITABILITY; CHILDHOOD; SYMPTOMS; METAANALYSIS;

D O I：

10.1038/s41386-020-0664-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective.

引用

页码：1617 / 1626

页数：10

共 50 条

[1] Shared Genetic Influences Between Attention-Deficit/Hyperactivity Disorder (ADHD) Traits in Children and Clinical ADHD
Stergiakouli, Evie
Martin, Joanna
Hamshere, Marian L.
Langley, Kate
Evans, David M.
St Pourcain, Beate
Timpson, Nicholas J.
Owen, Michael J.
O'Donovan, Michael
Thapar, Anita
Smith, George Davey
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2015, 54 (04) : 322 - 327
[2] Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan
Vilar-Ribo, Laura
Cabana-Dominguez, Judit
Martorell, Lourdes
Antoni Ramos-Quiroga, Josep
Sanchez-Roige, Sandra
Palmer, Abraham A.
Vilella, Elisabet
Ribases, Marta
Muntane, Gerard
Soler Artigas, Maria
NEUROPSYCHOPHARMACOLOGY, 2023, 48 (07) : 981 - 990
[3] Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Mattheisen, Manuel
Grove, Jakob
Als, Thomas D.
Martin, Joanna
Voloudakis, Georgios
Meier, Sandra
Demontis, Ditte
Bendl, Jaroslav
Walters, Raymond
Carey, Caitlin E.
Rosengren, Anders
Strom, Nora, I
Hauberg, Mads Engel
Zeng, Biao
Hoffman, Gabriel
Zhang, Wen
Bybjerg-Grauholm, Jonas
Baekvad-Hansen, Marie
Agerbo, Esben
Cormand, Bru
Nordentoft, Merete
Werge, Thomas
Mors, Ole
Hougaard, David M.
Buxbaum, Joseph D.
Faraone, Stephen, V
Franke, Barbara
Dalsgaard, Soren
Mortensen, Preben B.
Robinson, Elise B.
Roussos, Panos
Neale, Benjamin M.
Daly, Mark J.
Borglum, Anders D.
NATURE GENETICS, 2022, 54 (10) : 1470 - +
[4] Differentiation and comorbidity of bipolar disorder and attention deficit and hyperactivity disorder in children, adolescents, and adults: A clinical and nosological perspective
Comparelli, Anna
Polidori, Lorenzo
Sarli, Giuseppe
Pistollato, Andrea
Pompili, Maurizio
FRONTIERS IN PSYCHIATRY, 2022, 13
[5] Genetic Epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in Adults
Boomsma, Dorret I.
Saviouk, Viatcheslav
Hottenga, Jouke-Jan
Distel, Marijn A.
de Moor, Marleen H. M.
Vink, Jacqueline M.
Geels, Lot M.
van Beek, Jenny H. D. A.
Bartels, Meike
de Geus, Eco J. C.
Willemsen, Gonneke
PLOS ONE, 2010, 5 (05):
[6] Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment
O'Connell, Kevin S.
Shadrin, Alexey
Smeland, Olav B.
Bahrami, Shahram
Frei, Oleksandr
Bettella, Francesco
Krull, Florian
Fan, Chun C.
Askeland, Ragna B.
Knudsen, Gun Peggy S.
Halmoy, Anne
Steen, Nils Eiel
Ueland, Torill
Walters, G. Bragi
Davidsdottir, Katrin
Haraldsdottir, Gyda S.
Gudmundsson, Olafur O.
Stefansson, Hreinn
Reichborn-Kjennerud, Ted
Haavik, Jan
Dale, Anders M.
Stefansson, Kari
Djurovic, Srdjan
Andreassen, Ole A.
BIOLOGICAL PSYCHIATRY, 2020, 87 (12) : 1052 - 1062
[7] Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder
Guo, Xiaojie
Yao, Dongren
Cao, Qingjiu
Liu, Lu
Zhao, Qihua
Li, Hui
Huang, Fang
Wang, Yanfei
Qian, Qiujin
Wang, Yufeng
Calhoun, Vince D.
Johnstone, Stuart J.
Sui, Jing
Sun, Li
TRANSLATIONAL PSYCHIATRY, 2020, 10 (01)
[8] Background, clinical features and treatment of attention deficit hyperactivity disorder in children
Warikoo, Nisha
Faraone, Stephen V.
EXPERT OPINION ON PHARMACOTHERAPY, 2013, 14 (14) : 1885 - 1906
[9] Attention deficit hyperactivity disorder: genetic association study in a cohort of Spanish children
Gomez-Sanchez, Clara I.
Riveiro-Alvarez, Rosa
Soto-Insuga, Victor
Rodrigo, Maria
Tirado-Requero, Pilar
Mahillo-Fernandez, Ignacio
Abad-Santos, Francisco
Carballo, Juan J.
Dal-Re, Rafael
Ayuso, Carmen
BEHAVIORAL AND BRAIN FUNCTIONS, 2016, 12
[10] Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
Rommelse, Nanda N. J.
Franke, Barbara
Geurts, Hilde M.
Hartman, Catharina A.
Buitelaar, Jan K.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2010, 19 (03) : 281 - 295

← 1 2 3 4 5 →