Cellulases and beyond: the first 70 years of the enzyme producer Trichoderma reesei

被引：372

作者：

Bischof, Robert H. ^{[1
]}

Ramoni, Jonas ^{[2
]}

Seiboth, Bernhard ^{[1
,2
]}

机构：

[1] Vienna Univ Technol, Inst Chem Engn, Austrian Ctr Ind Biotechnol ACIB GmbH, A-1060 Vienna, Austria

[2] Vienna Univ Technol, Inst Chem Engn, Mol Biotechnol, Res Area Biochem Technol, Gumpendorferstr 1a, A-1060 Vienna, Austria

来源：

MICROBIAL CELL FACTORIES | 2016年 / 15卷

基金：

奥地利科学基金会;

关键词：

Trichoderma reesei; Cellulase; Recombinant protein production; Biorefinery; Lignocellulose; Gene expression; Consolidated bioprocessing; SACCHAROMYCES-CEREVISIAE; ETHANOL-PRODUCTION; CELLOBIOHYDROLASE-I; TRANSFORMATION SYSTEM; YEAST-STRAIN; TRANSCRIPTIONAL RESPONSE; HEMICELLULASE PRODUCTION; CELLULOLYTIC ACTIVITY; RECOMBINANT PROTEINS; GENETIC-IMPROVEMENT;

D O I：

10.1186/s12934-016-0507-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

More than 70 years ago, the filamentous ascomycete Trichoderma reesei was isolated on the Solomon Islands due to its ability to degrade and thrive on cellulose containing fabrics. This trait that relies on its secreted cellulases is nowadays exploited by several industries. Most prominently in biorefineries which use T. reesei enzymes to saccharify lignocellulose from renewable plant biomass in order to produce biobased fuels and chemicals. In this review we summarize important milestones of the development of T. reesei as the leading production host for biorefinery enzymes, and discuss emerging trends in strain engineering. Trichoderma reesei has very recently also been proposed as a consolidated bioprocessing organism capable of direct conversion of biopolymeric substrates to desired products. We therefore cover this topic by reviewing novel approaches in metabolic engineering of T. reesei.

引用

页数：13

共 173 条

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