Kojyl thioether derivatives having both tyrosinase inhibitory and anti-inflammatory properties

被引：78

作者：

Rho, Ho Sik ^{[1
]}

Ahn, Soo Mi ^{[1
]}

Yoo, Dae Sung ^{[3
]}

Kim, Myung Kyoo ^{[2
]}

Cho, Dong Ha ^{[3
]}

Cho, Jae Youl ^{[3
]}

机构：

[1] AmorePacific Corp, R&D Ctr, Yongin 446729, South Korea

[2] Samkyung Costech Co Ltd, Suwon 443734, South Korea

[3] Kangwon Natl Univ, Coll Biomed Sci, Chunchon 200701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 22期

关键词：

Kojyl thioether; Derivatives; Tyrosinase; Anti-inflammatory property; KOJIC ACID-DERIVATIVES; AMINO-ACID;

D O I：

10.1016/j.bmcl.2010.09.042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study was conducted to examine the tyrosinase inhibitory and anti-inflammatory activities of kojic acid derivatives. A series of kojic acid derivatives containing thioether, sulfoxide, and sulfone linkages were synthesized. In the tyrosinase assay, kojyl thioether derivatives containing appropriate lipophilic alkyl chains (pentane, hexane, and cyclohexane) showed potent inhibitory activity. However, sulfoxides and sulfones exhibited decreased activity. Similar experimental results were obtained with inhibitory activities of NO production being induced by LPS. The presence of thioether linkage and appropriated lipophilic acid moiety was critical for the tyrosinase inhibitory and anti-inflammatory activities. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：6569 / 6571

页数：3

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