Successful Treatment of Recalcitrant Juvenile Pemphigus Foliaceus with Intravenous Immunoglobulin and Rituximab

被引：1

作者：

Teo, Hock Gin ^{[1
]}

Lim, Tzyy Huei ^{[1
]}

Leong, Kin Fon ^{[2
]}

Muniandy, Pubalan ^{[1
]}

机构：

[1] Sarawak Gen Hosp, Dept Dermatol, Sarawak, Malaysia

[2] Women & Children Hosp Kuala Lumpur, Pediat Dermatol Unit, Kuala Lumpur, Malaysia

来源：

INDIAN JOURNAL OF PAEDIATRIC DERMATOLOGY | 2022年 / 23卷 / 03期

关键词：

Intravenous immunoglobulin; juvenile; pemphigus foliaccus; rituximab;

D O I：

10.4103/ijpd.ijpd_171_21

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Pemphigus foliaceus (PF) is uncommon among children. The usage of rituximab in childhood PF is even less documented. We reported a case of a 16-year-old boy with juvenile PF who failed conventional treatments and was started on combination therapy of intravenous immunoglobulin (IVIG) and rituximab followed by six-monthly rituximab maintenance therapy. He achieved full remission and no adverse effects. Therefore, in cases of recalcitrant juvenile PF, combination therapy of IVIG and rituximab can be considered.

引用

页码：245 / 248

页数：4

共 9 条

[1] Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin [J].

Ahmed, A. Razzaque ;

Spigelman, Zachary ;

Cavacini, Lisa A. ;

Posner, Marshall R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (17) :1772-1779

[2] Generalized erythrodermic pemphigus foliaceus in a child and its successful response to rituximab treatment [J].

Connelly, Elizabeth Alvarez ;

Aber, Cheryl ;

Kleiner, Gary ;

Nousari, Carlos ;

Charles, Carlos ;

Schachner, Lawrence A. .

PEDIATRIC DERMATOLOGY, 2007, 24 (02) :172-176

[3] Diagnosis and Clinical Features of Pemphigus Foliaceus [J].

James, Kirk A. ;

Culton, Donna A. ;

Diaz, Luis A. .

DERMATOLOGIC CLINICS, 2011, 29 (03) :405-+

[4] Updated S2K guidelines on the management of pemphigus vulgaris and foliaceus initiated by the european academy of dermatology and venereology (EADV) [J].

Joly, P. ;

Horwath, B. ;

Patsatsi, A. ;

Uzun, S. ;

Bech, R. ;

Beissert, S. ;

Bergman, R. ;

Bernard, P. ;

Borradori, L. ;

Caproni, M. ;

Caux, F. ;

Cianchini, G. ;

Daneshpazhooh, M. ;

De, D. ;

Dmochowski, M. ;

Drenovska, K. ;

Ehrchen, J. ;

Feliciani, C. ;

Goebeler, M. ;

Groves, R. ;

Guenther, C. ;

Hofmann, S. ;

Ioannides, D. ;

Kowalewski, C. ;

Ludwig, R. ;

Lim, Y. L. ;

Marinovic, B. ;

Marzano, A., V ;

Mascaro, J. M. Jr Jr ;

Mimouni, D. ;

Murrell, D. F. ;

Pincelli, C. ;

Squarcioni, C. P. ;

Sardy, M. ;

Setterfield, J. ;

Sprecher, E. ;

Vassileva, S. ;

Wozniak, K. ;

Yayli, S. ;

Zambruno, G. ;

Zillikens, D. ;

Hertl, M. ;

Schmidt, E. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2020, 34 (09) :1900-1913

[5]

Jones S K, 1986, Pediatr Dermatol, V3, P459, DOI 10.1111/j.1525-1470.1986.tb00651.x

[6] Pemphigus Foliaceus-Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report [J].

Kraft, Magdalena ;

Worm, Margitta .

FRONTIERS IN MEDICINE, 2018, 5

[7] Nonendemic pemphigus foliaceus in children [J].

Metry, DW ;

Hebert, AA ;

Jordon, RE .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 46 (03) :419-422

[8] Rituximab treatment of severe pemphigus: Long-term results including immunologic follow-up [J].

Reguiai, Ziad ;

Tabary, Thierry ;

Maizieres, Michael ;

Bernard, Philippe .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2012, 67 (04) :623-629

[9] Rituximab in refractory autoimmune bullous diseases [J].

Schmidt, E. ;

Hunzelmann, N. ;

Zillikens, D. ;

Broecker, E.-B. ;

Goebeler, M. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2006, 31 (04) :503-508

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