Rhodium-Catalyzed Successive C-H Bond Functionalizations To Synthesize Complex Indenols Bearing a Benzofuran Unit

被引：13

作者：

Mei, Yan-Le ^{[1
]}

Zhou, Wei ^{[1
]}

Huo, Tao ^{[1
]}

Zhou, Fang-Shuai ^{[1
]}

Xue, Jing ^{[1
]}

Zhang, Guang-Yi ^{[1
]}

Ren, Bing-Tao ^{[1
]}

Zhong, Cheng ^{[2
]}

Deng, Qing-Hai ^{[1
]}

机构：

[1] Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Joint Lab Int Cooperat Resource Chem, Educ Minist,Key Lab Resource Chem, Shanghai 200234, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, 199 Bayi Rd, Wuhan 430072, Hubei, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 23期

基金：

中国国家自然科学基金;

关键词：

N-PHENOXYACETAMIDES; DIRECTING GROUPS; PRIVILEGED SCAFFOLD; DRUG DISCOVERY; ACTIVATION; ALKYNES; ANNULATION; CARBOCYCLIZATION; DERIVATIVES; KETONES;

D O I：

10.1021/acs.orglett.9b03766

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient rhodium-catalyzed redox-neutral annulations of N-phenoxyacetamides and ynones via successive double C-H bond activations has been developed. A series of novel and complex indenols bearing a benzofuran unit were generated with moderate to excellent regioselecetivities under mild conditions. Adding N-ethylcyclohexanamine (CyNHEt) could restrict the formation of the mono C-H bond activation byproduct, which is not the intermediate of the reaction demonstrated via the mechanistic investigations.

引用

页码：9598 / 9602

页数：5

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