Molecular design of metalloporphyrin as oxidative cleavage agent for DNA in site-sequence specific way

被引：0
|
作者：
He, HS [1 ]
机构：
[1] Natl Huaqiao Univ, Sch Chem Engn, Quanzhou 362011, Peoples R China
来源：
PROGRESS IN CHEMISTRY | 2001年 / 13卷 / 03期
关键词：
metalloporphyrins; DNA; recognition in site-sequence specific way; oxidative cleavage;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metalloporphyrin as a site-sequence specific cleavage agent of nucleic acids plays an important role in the design of structural probes and therapeutic agents. Metalloporphyrins linked to the special groups (oligonucleotides, peptides, acridine etc.) can cleave the DNA in a sequence specific ways in the presence of oxidants, which will have a potential application in molecular biology. This article reviews the design, synthesis and oxidation properties of various metalloporphyrin-related cleavage agents in recent years.
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页码：216 / 223
页数：8
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