Effect of in utero and early-life conditions on adult health and disease

被引：2760
作者：
Gluckman, Peter D. [1 ,2 ]
Hanson, Mark A. [3 ]
Cooper, Cyrus [4 ]
Thornburg, Kent L. [5 ]
机构：
[1] Univ Auckland, Liggins Inst, Auckland 1, New Zealand
[2] Natl Res Ctr Growth & Dev, Auckland, New Zealand
[3] Univ Southampton, Inst Dev Sci, Southampton, Hants, England
[4] Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton, Hants, England
[5] Oregon Hlth & Sci Univ, Heart Res Ctr, Portland, OR 97201 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 359卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1056/NEJMra0708473
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Many lines of evidence, including epidemiologic data and extensive clinical and experimental studies, indicate that early life events play a powerful role in influencing later susceptibility to certain chronic diseases. This review synthesizes evidence from several disciplines to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation. Copyright © 2008 Massachusetts Medical Society.
引用
收藏
页码：61 / 73
页数：13
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