One-Step Way to Form Prodrug Micelles with High Amount Drug Loading

被引：2

作者：

Zhang, Jing ^{[1
]}

Wu, Dan ^{[1
]}

Feng, Jie ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Mat Sci & Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2016年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Prodrug; One-Step; Hydrazone Bonds; Drug Content; Drug Delivery; POLYMERIC MICELLES; IN-VIVO; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; TUMOR; PH; NANOPARTICLES; DOXORUBICIN; CANCER; CELLS;

D O I：

10.1166/jnn.2016.11740

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Prodrug micelles with high amount drug loading were obtained via one-step way. Antineoplastic drug doxorubicin (DOX), used as hydrophobic tail, was conjugated to hydrophilic head mPEG via hydrazone bonds, allowing drug release under intracellular condition. Free DOX was loaded into the hydrophobic core of micelles during the conjugation step simultaneously. Total drug content of the prodrug micelles was up to 61.2%. Endocytosis experiments confirmed that the prodrug micelles achieved good cellular-uptake ability. In vitro experiments indicated that the prodrug micelles showed better therapy efficacy than free drug in cancerous cells.

引用

页码：5586 / 5591

页数：6

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