Changes in glutamate receptor subunit 4 expression in the deafferented olfactory bulb of zebrafish

被引:6
作者
Fuller, CL [1 ]
Villanueva, R [1 ]
Byrd, CA [1 ]
机构
[1] Western Michigan Univ, Dept Biol Sci, Kalamazoo, MI 49008 USA
关键词
iGluR4; AMPA receptor; zebrafish; olfactory bulb; deafferentation; periglomerular cells;
D O I
10.1016/j.brainres.2005.03.012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The distribution of ionotropic glutamate receptor subunit 4 (iGluR4) was examined in both normal and deafferented olfactory bulbs of adult zebrafish, Danio rerio. With the exception of the olfactory nerve layer, there was extensive labeling with antibodies to iGluR4 in the olfactory bulbs, specifically in juxtaglomerular cell bodies and their processes. These results are consistent with previous work, which has suggested differential distribution of glutamate receptors in the vertebrate olfactory system. Analysis of bulbs following olfactory organ removal revealed a significant loss of iGluR4 immunoreactivity by 24 h post-deafferentation. At 48 h after denervation, iGluR4 labeling had returned to normal levels and was retained through 3 weeks post-surgery. Thus, afferent input plays a role in reduced labeling of this protein immediately following injury, but return of inummoreactivity can occur even without sensory innervation. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:251 / 261
页数:11
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