Backscattering spectroscopic contrast with angle-resolved optical coherence tomography

被引:9
作者
Desjardins, Adrien E. [1 ]
Vakoc, Benjamin J.
Tearney, Guillermo J.
Bouma, Brett E.
机构
[1] Harvard Univ, Sch Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
关键词
D O I
10.1364/OL.32.003158
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Backscattering spectroscopic contrast using angle-resolved optical coherence tomography is demonstrated as a powerful method for determining scatterer diameter with subwavelength resolution. By applying spectroscopic digital processing algorithms to interferograms acquired in the frequency domain with a wavelength-swept laser centered at 1295 nm, it was shown that differences in wavelength-dependent backscattering from 0.3 and 1 mu m diameter microspheres can be clearly resolved. The observed backscattering spectra were found to be consistent with Mie theory. High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated. (c) 2007 Optical Society of America
引用
收藏
页码:3158 / 3160
页数:3
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