Telomere and telomerase as targets for anti-cancer and regeneration therapies

被引：17

作者：

Hsu, YH ^{[1
]}

Lin, JJ ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei, Taiwan

来源：

ACTA PHARMACOLOGICA SINICA | 2005年 / 26卷 / 05期

关键词：

telomere; telomerase; cancer; regenerative disease; gene therapy;

D O I：

10.1111/j.1745-7254.2005.00098.x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Telomerase is a ribonucleoprotein that directs the synthesis of telomeric sequence. It is detected in majority of malignant tumors, but not in most normal somatic cells. Because telomerase plays a critical role in cell immortality and tumor formation, it has been one of the targets for anti-cancer and regeneration drug development. In this review, we will discuss therapeutic approaches based mainly on small molecules that have been developed to inhibit telomerase activity, modulate telomerase expression, and telomerase directed gene therapy.

引用

页码：513 / 518

页数：6

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