Allenic and cumulenic lipids

被引：150

作者：

Dembitsky, Valery M.

Maoka, Takashi

机构：

[1] Hebrew Univ Jerusalem, Sch Pharm, Dept Med Chem & Nat Prod, IL-91120 Jerusalem, Israel

[2] Res Inst Prod Dev, Sakyo Ku, Kyoto 6060805, Japan

[3] Kyoto Pharmaceut Univ, Kyoto, Japan

来源：

PROGRESS IN LIPID RESEARCH | 2007年 / 46卷 / 06期

关键词：

fatty acids; lipids; triacylglycerides; hydrocarbons; allenic; cumulenic; anticancer; antiviral; antibacterial; terpenoids; Carotenoids; steroids; peptides aromatic; synthetic;

D O I：

10.1016/j.plipres.2007.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nowadays, about 200 natural allenic metabolites, more than 2700 synthetic allenic compounds, and about 1300 cumulenic structures are known. The present review describes research on natural as well as some biological active allenic and cumulenic lipids and related compounds isolated from different sources. Intensive searches for new classes of pharmacologically potent agents produced by living organisms have resulted in the discovery of dozens of such compounds possessing high anticancer, cytotoxic, antibacterial, antiviral, and other activities. Known allenic and cumulenic compounds can be subdivided on several structural classes: fatty acids, hydrocarbons, terpenes, steroids, carotenoids, marine bromoallenes, peptides, aromatic, cumulenic, and miscellaneous compounds. This review emphasizes the role of natural and synthetic allenic and cumulenic lipids and other related compounds as an important source of leads for drug discovery. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：328 / 375

页数：48

共 366 条

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