Obesity and hormone-dependent tumors: Cohort and co-twin control studies based on the Swedish Twin Registry

被引:83
作者
Jonsson, F
Wolk, A
Pedersen, NL
Lichtenstein, P
Terry, P
Ahlbom, A
Feychting, M
机构
[1] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden
[3] Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx, NY 10467 USA
关键词
obesity; hormone-dependent tumor; body mass index; anthropometry;
D O I
10.1002/ijc.11266
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Obesity increases the risk of certain cancer types, e.g., cancer of the endometrium, colon and gallbladder. For some other cancer forms, e.g., prostate cancer, the association is less clear. We examined the association between body mass index (BMI) and hormone-dependent tumors, utilizing a cohort of 21,884 Swedish twins born during 1886-1925. Information about BMI at different ages and potential confounding factors was collected prospectively. The Swedish Cancer Registry was used to identify cases of cancer in the prostate (n = 666), breast (n = 607), corpus uteri (n = 150) and ovary (n = 118) during 1969-1997. The material was analyzed as a traditional cohort and with co-twin control analyses that allow for control of genetic influences. Obesity (BMI greater than or equal to 30 kg/m(2)) at baseline was positively associated with cancer in the corpus uteri [relative risk (RR) = 3.03, 95% confidence interval (CI) 1.82-5.03], as was BMI at age 25, independently of BMI at baseline. Increased risk was also found for breast cancer but only in older women (greater than or equal to70 years). Overweight at age 25 was associated with decreased risk of breast cancer (RR = 0.51, 95% CI 0.33-0.78). No association was found for prostate cancer. We conclude that age is an important effect modifier of cancer risk associated with obesity and that obesity and overweight in young adult life may affect cancer risk also later in life. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:594 / 599
页数:6
相关论文
共 46 条
[1]   Body size and prostate cancer: A 20-year follow-up study among 135006 Swedish construction workers [J].
Andersson, SO ;
Wolk, A ;
Bergstrom, R ;
Adami, HO ;
Engholm, G ;
Englund, A ;
Nyren, O .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (05) :385-389
[2]   Genetics of body-weight regulation [J].
Barsh, GS ;
Farooqi, IS ;
O'Rahilly, S .
NATURE, 2000, 404 (6778) :644-651
[3]  
Calle EE, 2000, AM J EPIDEMIOL, V151, P550, DOI 10.1093/oxfordjournals.aje.a010242
[4]  
CEDERLOEF R, 1961, ACTA GENET STAT MED, V11, P338
[5]   Body size indices at different ages and epithelial ovarian cancer risk [J].
Dal Maso, L ;
Franceschi, S ;
Negri, E ;
Conti, E ;
Montella, M ;
Vaccarella, S ;
Canzonieri, V ;
Parazzini, F ;
La Vecchia, C .
EUROPEAN JOURNAL OF CANCER, 2002, 38 (13) :1769-1774
[6]   ASSOCIATION OF OBESITY AND OVARIAN-CANCER IN A CASE-CONTROL STUDY [J].
FARROW, DC ;
WEISS, NS ;
LYON, JL ;
DALING, JR .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1989, 129 (06) :1300-1304
[7]  
FIELD AE, 1994, J CLIN ENDOCR METAB, V79, P1310, DOI 10.1210/jc.79.5.1310
[8]   Review of anthropometric factors and breast cancer risk [J].
Friedenreich, CM .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2001, 10 (01) :15-32
[9]   Insulin-like growth factors and cancer [J].
Fürstenberger, G ;
Senn, HJ .
LANCET ONCOLOGY, 2002, 3 (05) :298-302
[10]   Energy balance and cancers [J].
Gerber, M ;
Corpet, D .
EUROPEAN JOURNAL OF CANCER PREVENTION, 1999, 8 (02) :77-89