Treatment of brain metastases in ALK-positive non-small cell lung cancer

被引：18

作者：

Ceddia, Serena ^{[1
]}

Codacci-Pisanelli, Giovanni ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Med & Surg Sci & Biotechnol, Corso Repubbl 79, I-04100 Latina, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 165卷

关键词：

Brain metastases; ALK-translocation; Crizotinib; Alectinib; Lorlatinib; Brigatinib; LYMPHOMA KINASE ALK; OPEN-LABEL; RADIATION-THERAPY; TARGETED THERAPY; SINGLE-ARM; J-ALEX; CRIZOTINIB; ALECTINIB; CHEMOTHERAPY; CERITINIB;

D O I：

10.1016/j.critrevonc.2021.103400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastases are quite frequent in patients with ALK-translocated non-small cell lung cancer (NSCLC): they are often not amenable to surgical resection and are generally treated with radiotherapy (RT). This however causes severe late toxic side effects that may become invalidating considering the relatively long survival provided by recent medical treatment with target therapies. Several clinical trials have demonstrated that ALKinhibitors (crizotinib, alectinib, brigatinib) show excellent activity also against brain metastases. It is therefore reasonable, in asymptomatic patients, to start treatment with specific inhibitors: RT will be used at the time of tumor progression or when symptoms appear. This sequence provides the best quality of life for patients.

引用

页数：8

共 75 条

[1] Brigatinib in Crizotinib-Refractory ALK plus NSCLC: Updated Efficacy and Safety Results From ALTA, a Randomized Phase 2 Trial [J].

Ahn, M. ;

Camidge, D. R. ;

Tiseo, M. ;

Reckamp, K. ;

Hansen, K. ;

Kim, S. ;

Huber, R. ;

West, H. ;

Groen, H. ;

Hochmair, M. ;

Leighl, N. ;

Gettinger, S. ;

Langer, C. ;

Paz-Ares, L. ;

Smit, E. ;

Kim, E. ;

Reichmann, W. ;

Kerstein, D. ;

Kim, D. .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) :S1755-S1756

[2] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases - A randomized controlled trial [J].

Aoyama, Hidefumi ;

Shirato, Hiroki ;

Tago, Masao ;

Nakagawa, Keiichi ;

Toyoda, Tatsuya ;

Hatano, Kazuo ;

Kenjyo, Masahiro ;

Oya, Natsuo ;

Hirota, Saeko ;

Shioura, Hiroki ;

Kunieda, Etsuo ;

Inomata, Taisuke ;

Hayakawa, Kazushige ;

Katoh, Norio ;

Kobashi, Gen .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (21) :2483-2491

[3] Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01) [J].

Barlesi, F. ;

Gervais, R. ;

Lena, H. ;

Hureaux, J. ;

Berard, H. ;

Paillotin, D. ;

Bota, S. ;

Monnet, I. ;

Chajara, A. ;

Robinet, G. .

ANNALS OF ONCOLOGY, 2011, 22 (11) :2466-2470

[4] Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer [J].

Bauer, Todd M. ;

Shaw, Alice T. ;

Johnson, Melissa L. ;

Navarro, Alejandro ;

Gainor, Justin F. ;

Thurm, Holger ;

Pithavala, Yazdi K. ;

Abbattista, Antonello ;

Peltz, Gerson ;

Felip, Enriqueta .

TARGETED ONCOLOGY, 2020, 15 (01) :55-65

[5] Concomitant radiotherapy and TKI in metastatic EGFR- or ALK-mutated non-small cell lung cancer: a multicentric analysis on behalf of AIRO lung cancer study group [J].

Borghetti, Paolo ;

Bonu, Marco Lorenzo ;

Giubbolini, Rachele ;

Levra, Niccolo' Giaj ;

Mazzola, Rosario ;

Perna, Marco ;

Visani, Luca ;

Meacci, Fiammetta ;

Taraborrelli, Maria ;

Triggiani, Luca ;

Franceschini, Davide ;

Greco, Carlo ;

Bruni, Alessio ;

Magrini, Stefano Maria ;

Scotti, Vieri .

RADIOLOGIA MEDICA, 2019, 124 (07) :662-670

[6] Whole brain radiotherapy for brain metastases [J].

Brown, Paul D. .

BMJ-BRITISH MEDICAL JOURNAL, 2016, 355

[7] Treatment of lung adenocarcinoma brain metastases: what is the role of radiotherapy in the age of precision medicine? [J].

Buss, Elizabeth J. ;

Wang, Tony J. C. .

TRANSLATIONAL LUNG CANCER RESEARCH, 2018, 7 :S318-S320

[8] Brigatinib versus Crizotinib in ALK-Positive Non-Small-Cell Lung Cancer [J].

Camidge, D. R. ;

Kim, H. R. ;

Ahn, M. -J. ;

Yang, J. C. -H. ;

Han, J. -Y. ;

Lee, J. -S. ;

Hochmair, M. J. ;

Li, J. Y. -C. ;

Chang, G. -C. ;

Lee, K. H. ;

Gridelli, C. ;

Delmonte, A. ;

Garcia Campelo, R. ;

Kim, D. -W. ;

Bearz, A. ;

Griesinger, F. ;

Morabito, A. ;

Felip, E. ;

Califano, R. ;

Ghosh, S. ;

Spira, A. ;

Gettinger, S. N. ;

Tiseo, M. ;

Gupta, N. ;

Haney, J. ;

Kerstein, D. ;

Popat, S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 379 (21) :2027-2039

[9]

Camidge DR, 2015, J CLIN ONCOL, V33

[10] Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial [J].

Chang, Eric L. ;

Wefel, Jeffrey S. ;

Hess, Kenneth R. ;

Allen, Pamela K. ;

Lang, Frederick F. ;

Kornguth, David G. ;

Arbuckle, Rebecca B. ;

Swint, J. Michael ;

Shiu, Almon S. ;

Maor, Moshe H. ;

Meyers, Christina A. .

LANCET ONCOLOGY, 2009, 10 (11) :1037-1044

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