All-In-One Second Near-Infrared Light-Responsive Drug Delivery System for Synergistic Chemo-Photothermal Therapy

被引：12

作者：

Zhou, Tianxing ^{[1
]}

Xie, Shuangcong ^{[2
]}

Zhou, Chunze ^{[3
]}

Chen, Yiyu ^{[2
,4
]}

Li, Hong ^{[5
]}

Liu, Ping ^{[2
]}

Jiang, Rongjian ^{[1
]}

Hang, Lifeng ^{[2
]}

Jiang, Guihua ^{[1
,2
]}

机构：

[1] Guangdong Med Univ, Zhanjiang 524023, Peoples R China

[2] Guangdong Second Prov Gen Hosp, Dept Med Imaging, Guangzhou 518037, Peoples R China

[3] Univ Sci & Technol China, Affiliated Hosp 1, Intervent Radiol Dept, Div Life Sci & Med, Hefei 230001, Peoples R China

[4] Southern Med Univ, Sch Forens Med, P, R China, Guangzhou 510515, Peoples R China

[5] Jinan Univ, Coll Chem & Mat Sci, Guangzhou 518037, Peoples R China

来源：

ACS APPLIED BIO MATERIALS | 2022年 / 5卷 / 08期

基金：

中国国家自然科学基金;

关键词：

  nanocarrier-based drug delivery systems; hollow copper sulfide nanoparticles; NIR-II light-responsive; doxorubicin; chemo-photothermal therapy; COPPER SULFIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; CALRETICULIN EXPOSURE; CHECKPOINT BLOCKADE; GOLD NANORODS; CANCER; CHEMOTHERAPY; COMBINATION; DOXORUBICIN; RELEASE;

D O I：

10.1021/acsabm.2c00208

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

ABSTRACT: Light-responsive nanocarrier-based drug delivery systems (NDDSs), due to their unique advantages such as safety, minimal cross-reaction, and spatiotemporal precision, have light, which has a high penetration depth for manipulating NDDSs to release drugs, is in high demand. Herein, polyethylene glycol (PEG)-modified hollow CuxS nanoparticles (NPs) are developed as an all-in-one NIR-II light-responsive NDDS for synergistic chemo-photothermal therapy. First, CuxS-PEG NPs were prepared under mild conditions by using Cu2O NPs as sacrificial templates. The morphology, photothermal effect, drug loading/releasing abilities, and synergistic chemo-photothermal therapy of CuxSPEG NPs have been investigated. The CuxS-PEG NPs with hollow structures showed a high drug loading capacity (similar to 255 mu g Dox per mg of CuxS NPs) and stimuli-responsive drug release triggered by NIR-II laser irradiation. The synergistic chemo-photothermal therapy based on the Dox/CuxS-PEG NPs showed 98.5% tumor elimination. Our study emphasizes the great potential of CuxS-PEG NPs as an all-in-one NIR-II light-responsive NDDS for applications in biomedicine.

引用

页码：3841 / 3849

页数：9

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