Adaptation of HIV-1 envelope gp120 to humoral immunity at a population level

被引：93

作者：

Bunnik, Evelien M. ^{[1
]}

Euler, Zelda ^{[1
]}

Welkers, Matthijs R. A. ^{[1
]}

Boeser-Nunnink, Brigitte D. M. ^{[1
]}

Grijsen, Marlous L. ^{[2
]}

Prins, Jan M. ^{[2
]}

Schuitemaker, Hanneke ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Ctr Infect & Immun Amsterdam,Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Ctr Infect & Immun Amsterdam, Dept Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands

来源：

NATURE MEDICINE | 2010年 / 16卷 / 09期

关键词：

NEUTRALIZING ANTIBODY-RESPONSE; TYPE-1; INFECTION; C INFECTION; VIRUS; SENSITIVITY; EVOLUTION; DOMAIN;

D O I：

10.1038/nm.2203

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By comparing HIV-1 variants from people who became infected at the beginning of the epidemic and from people who have recently contracted the virus, we observed an enhanced resistance of the virus to antibody neutralization over time, accompanied by an increase in the length of the variable loops and in the number of potential N-linked glycosylation sites on the HIV-1 envelope gp120 subunit. The enhanced neutralization resistance of HIV-1 in contemporary seroconverters coincided with the poorer elicitation of neutralizing antibody responses, which may have implications for vaccine design.

引用

页码：995 / 997

页数：3

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