Optimizing real time fMRI neurofeedback for therapeutic discovery and development

被引：145

作者：

Stoeckel, L. E. ^{[1
,2
,3
,4
]}

Garrison, K. A. ^{[5
]}

Ghosh, S. S. ^{[4
]}

Wighton, P. ^{[3
,6
]}

Hanlon, C. A. ^{[7
]}

Gilman, J. M. ^{[1
,2
,3
]}

Greer, S. ^{[8
]}

Turk-Browne, N. B. ^{[9
]}

deDettencourt, M. T. ^{[10
]}

Scheinost, D. ^{[11
]}

Craddock, C. ^{[12
]}

Thompson, T. ^{[4
]}

Calderon, V. ^{[1
]}

Bauer, C. C. ^{[13
]}

George, M. ^{[7
]}

Breiter, H. C. ^{[1
,14
]}

Whitfield-Gabrieli, S. ^{[4
]}

Gabrieli, J. D. ^{[4
]}

LaConte, S. M. ^{[15
,16
]}

Hirshberg, L. ^{[17
]}

Brewer, J. A. ^{[5
,18
]}

Hampson, M. ^{[11
]}

Van der Kouwe, A. ^{[3
,6
]}

Mackey, S. ^{[19
]}

Evins, A. E. ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Cambridge, MA 02138 USA

[3] Athinoula A Martinos Ctr, Charlestown, MA USA

[4] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA

[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

[6] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[7] Med Univ S Carolina, Dept Psychiat, Charleston, SC USA

[8] Univ Calif Berkeley, Dept Neurosci, Berkeley, CA 94720 USA

[9] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA

[10] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

[11] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA

[12] Child Mind Inst, New York, NY USA

[13] Univ Nacl Autonoma Mexico, Inst Neurobiol, Mexico City 04510, DF, Mexico

[14] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Evanston, IL 60208 USA

[15] Virginia Tech, Sch Biomed Engn & Sci, Blacksburg, VA USA

[16] Virginia Tech, Carilion Res Inst, Blacksburg, VA USA

[17] Brown Univ, Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA

[18] Univ Massachusetts, Sch Med, Dept Med & Psychiat, Amherst, MA 01003 USA

[19] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA

来源：

NEUROIMAGE-CLINICAL | 2014年 / 5卷

基金：

美国国家卫生研究院;

关键词：

Real time fMRI; Neurotherapeutic; Neurofeedback; Brain-computer interface; CINGULATE CORTEX ACTIVITY; SELF-REGULATION; BRAIN ACTIVITY; SELECTIVE ATTENTION; LEARNED REGULATION; COGNITIVE CONTROL; ACTIVATION; PLASTICITY; REDUCTION; CHILDREN;

D O I：

10.1016/j.nicl.2014.07.002

中图分类号：

R445 [影像诊断学];

学科分类号：

100207 ;

摘要：

While reducing the burden of brain disorders remains a top priority of organizations like the World Health Organization and National Institutes of Health, the development of novel, safe and effective treatments for brain disorders has been slow. In this paper, we describe the state of the science for an emerging technology, real time functional magnetic resonance imaging (rtfMRI) neurofeedback, in clinical neurotherapeutics. We review the scientific potential of rtfMRI and outline research strategies to optimize the development and application of rtfMRI neurofeedback as a next generation therapeutic tool. We propose that rtfMRI can be used to address a broad range of clinical problems by improving our understanding of brain-behavior relationships in order to develop more specific and effective interventions for individuals with brain disorders. We focus on the use of rtfMRI neurofeedback as a clinical neurotherapeutic tool to drive plasticity in brain function, cognition, and behavior. Our overall goal is for rtfMRI to advance personalized assessment and intervention approaches to enhance resilience and reduce morbidity by correcting maladaptive patterns of brain function in those with brain disorders. (C) 2014 The Authors. Published by Elsevier Inc.

引用

页码：245 / 255

页数：11

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