Liposomal curcumin and its application in cancer

被引：299

作者：

Feng, Ting ^{[1
]}

Wei, Yumeng ^{[1
]}

Lee, Robert J. ^{[2
]}

Zhao, Ling ^{[1
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmaceut, 3-5 Zhongshan Rd, Luzhou 646099, Sichuan, Peoples R China

[2] Ohio State Univ, Coll Pharm, Div Pharmaceut, 500 W 12Th Ave, Columbus, OH 43210 USA

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2017年 / 12卷

基金：

中国国家自然科学基金;

关键词：

curcumin; liposomes; drug delivery; bioavailability; cancer; BREAST-CONSERVING SURGERY; IN-VITRO; PROSTATE-CANCER; DRUG-DELIVERY; ORAL DELIVERY; LIVER-CANCER; TUMOR-GROWTH; PHYSICOCHEMICAL PROPERTIES; ENCAPSULATING CURCUMIN; CHEMOPREVENTIVE AGENT;

D O I：

10.2147/IJN.S132434

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

引用

页码：6027 / 6044

页数：18

共 142 条

[1] Curcuminoids-loaded liposomes in combination with arteether protects against Plasmodium berghei infection in mice [J].

Aditya, N. P. ;

Chimote, Geetanjali ;

Gunalan, Karthigayan ;

Banerjee, Rinti ;

Patankar, Swati ;

Madhusudhan, Basavaraj .

EXPERIMENTAL PARASITOLOGY, 2012, 131 (03) :292-299

[2]

Aggarwal BB, 2003, ANTICANCER RES, V23, P363

[3] Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases [J].

Aggarwal, Bharat B. ;

Harikumar, Kuzhuvelil B. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (01) :40-59

[4] Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells [J].

Akkoc, Yunus ;

Berrak, Ozge ;

Arisan, Elif Damla ;

Obakan, Pinar ;

Coker-Gurkan, Ajda ;

Palavan-Unsal, Narcin .

BIOMEDICINE & PHARMACOTHERAPY, 2015, 71 :161-171

[5] Bioavailability of curcumin: Problems and promises [J].

Anand, Preetha ;

Kunnumakkara, Ajaikumar B. ;

Newman, Robert A. ;

Aggarwal, Bharat B. .

MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818

[6] In vitro delivery of curcumin with cholesterol-based cationic liposomes [J].

Apiratikul, N. ;

Penglong, T. ;

Suksen, K. ;

Svasti, S. ;

Chairoungdua, A. ;

Yingyongnarongkul, B. .

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2013, 39 (04) :444-450

[7] A randomized controlled phase II trial of a novel composition of paclitaxel embedded into neutral and cationic lipids targeting tumor endothelial cells in advanced triple-negative breast cancer (TNBC) [J].

Awada, A. ;

Bondarenko, I. N. ;

Bonneterre, J. ;

Nowara, E. ;

Ferrero, J. M. ;

Bakshi, A. V. ;

Wilke, C. ;

Piccart, M. .

ANNALS OF ONCOLOGY, 2014, 25 (04) :824-831

[8] Circulation and biodistribution profiles of long-circulating PEG-liposomes of various sizes in rabbits [J].

Awasthi, VD ;

Garcia, D ;

Goins, BA ;

Phillips, WT .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 253 (1-2) :121-132

[9]

Axelsson H, 2007, CANCER INFORM, V3, P125

[10] Undulation instability in a bilayer lipid membrane due to electric field interaction with lipid dipoles [J].

Bingham, Richard J. ;

Olmsted, Peter D. ;

Smye, Stephen W. .

PHYSICAL REVIEW E, 2010, 81 (05)

← 1 2 3 4 5 6 7 8 9 10 →