Atypical carcinoid tumor of the thymus with ectopic ACTH production developed during the course of etanercept treatment - case report

被引：6

作者：

Simsek, Ismail ^{[1
]}

Pay, Salih

Dinc, Ayhan

Erdem, Hakan

Kurt, Bulent

机构：

[1] Gulhane Mil Med Acad, Dept Med, Div Rheumatol, TR-06018 Ankara, Turkey

[2] Gulhane Mil Med Acad, Dept Pathol, TR-06018 Ankara, Turkey

来源：

CLINICAL RHEUMATOLOGY | 2007年 / 26卷 / 09期

关键词：

anti-TNF; etanercept; malignancy; thymic; tumor necrosis factor;

D O I：

10.1007/s10067-006-0454-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ever since the introduction of anti-tumor necrosis factor (TNF) agents, concerns have been raised regarding their potential for developing malignancy. We report the development of thymic atypical carcinoid tumor 9 months after the initiation of etanercept therapy in a patient having refractory spondylarthritis. This case indicates the need for following large cohorts of patients receiving anti-TNF agents to address the long-term effect of these agents on malignancies.

引用

页码：1561 / 1562

页数：2

共 8 条

[1] Acute myelogenous leukaemia following etanercept therapy [J].

Bakland, G ;

Nossent, H .

RHEUMATOLOGY, 2003, 42 (07) :900-901

[2]

Brandom RB, 2002, BOUNDARY TWO, V29, P1

[3] Tumor necrosis factor antagonist therapy and lymphoma development - Twenty-six cases reported to the Food and Drug Administration [J].

Brown, SL ;

Greene, MH ;

Gershon, SK ;

Edwards, ET ;

Braun, MM .

ARTHRITIS AND RHEUMATISM, 2002, 46 (12) :3151-3158

[4]

Esser AC, 2004, J AM ACAD DERMATOL, V50, pS75

[5] Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas [J].

Geborek, P ;

Bladström, A ;

Turesson, C ;

Gulfe, A ;

Petersson, IF ;

Saxne, T ;

Olsson, H ;

Jacobsson, LTH .

ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (05) :699-703

[6] Safety of tumour necrosis factor-α antagonists [J].

Khanna, D ;

McMahon, M ;

Furst, DE .

DRUG SAFETY, 2004, 27 (05) :307-324

[7] Crohn's colitis presenting with node-negative colon cancer and liver metastasis after therapy with infliximab: Report of two cases [J].

Nicholson, T ;

Orangio, GR ;

Brandenburg, D ;

Wolf, DC ;

Pennington, EE .

DISEASES OF THE COLON & RECTUM, 2005, 48 (08) :1651-1655

[8] A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus [J].

Tiffet, O ;

Nicholson, AG ;

Ladas, G ;

Sheppard, MN ;

Goldstraw, P .

CHEST, 2003, 124 (01) :141-146

← 1 →