Association of glutathione S-transferase M1 and T1 gene polymorphisms and oxidative stress markers in preterm labor

被引：39

作者：

Mustafa, M. D. ^{[1
]}

Pathak, Rahul ^{[1
]}

Ahmed, Tanzeel ^{[1
]}

Ahmed, Rafat S. ^{[1
]}

Tripathi, A. K. ^{[1
]}

Guleria, Kiran ^{[2
]}

Banerjee, B. D. ^{[1
]}

机构：

[1] Dept Biochem, Environm Biochem & Mol Biol Lab, Delhi 110095, India

[2] Univ Delhi, Dept Obstet & Gynaecol, Univ Coll Med Sci, Delhi 1100953, India

来源：

CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 13-14期

关键词：

Preterm labor; Reactive oxygen species; Oxidative stress; Glutathione S-transferase; Genetic polymorphism; ENVIRONMENT; INFERTILITY; PLASMA; BLOOD; BIRTH; TERM;

D O I：

10.1016/j.clinbiochem.2010.06.018

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: Oxidative stress and related gene polymorphism may be associated with the etiology of preterm labor (PTL). The present study was designed to investigate association of GSTM1 and GSTT1 gene polymorphisms with PTL and their relationship with oxidative stress markers. Design and methods: Sixty cases of PTL and sixty three subjects of full term labor (FTL) were included in the study. Multiplex PCR was performed for GSTM1 and GSTT1 genes polymorphism and oxidative stress markers were analyzed. Result: MDA. and 8-OHdG levels were increased, while GSH was decreased in PTL than FTL subjects. Frequency of GSTM1-/GSTT1-( null) was significantly higher in PTL in comparison to FTL (p = 0.028, OR = 3.4). Subjects with GSTM1-/GSTT1+, GSTM1+/GSTT1-, GSTM1-/GSTT1- have significant differences of oxidative stress markers as compared to GSTM1+/GSTT1+ genotype. Conclusion: GSTM1-/GSTT1- (null) genotype may be one of the associated genetic factor for the increased risk of PTL. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1124 / 1128

页数：5

共 36 条

[1] Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype [J].

Aydemir, Birsen ;

Onaran, Ilhan ;

Kiziler, Ali R. ;

Alici, Bulent ;

Akyolcu, Mehmet C. .

ASIAN JOURNAL OF ANDROLOGY, 2007, 9 (01) :108-115

[2] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].

Benzie, IFF ;

Strain, JJ .

ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76

[3] The role of glutathione S- transferase M1 and T1 gene polymorphisms and oxidative stress-related parameters in Egyptian patients with essential hypertension [J].

Bessa, Sahar S. ;

Ali, Ehab M. M. ;

Hamdy, Soha M. .

EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2009, 20 (06) :625-630

[4]

BOARD PG, 1981, AM J HUM GENET, V33, P36

[5] Beneficial impact of term labor: Nonenzymatic antioxidant reserve in the human fetus [J].

Buhimschi, IA ;

Buhimschi, CS ;

Pupkin, M ;

Weiner, CP .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2003, 189 (01) :181-188

[6]

Dennery Phyllis A., 2007, Birth Defects Research, V81, P155, DOI 10.1002/bdrc.20098

[7] Preterm labour and delivery: a genetic predisposition [J].

Dizon-Townson, DS .

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2001, 15 :57-62

[8] Glutathione recycling and antioxidant enzyme activities in erythrocytes of term and preterm newborns at birth [J].

Frosali, S ;

Di Simplicio, P ;

Perrone, S ;

Di Giuseppe, D ;

Longini, M ;

Tanganelli, D ;

Buonocore, G .

BIOLOGY OF THE NEONATE, 2004, 85 (03) :188-194

[9] Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system [J].

Fujii, J ;

Iuchi, Y ;

Okada, F .

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2005, 3 (1)

[10]

Gupta S, 2009, INT J FERTIL STERIL, V2, P147

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