Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum

被引：3

作者：

Castellino, Robert C. ^{[1
]}

Kenney, Anna Marie ^{[1
]}

机构：

[1] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA

来源：

DEVELOPMENTAL CELL | 2019年 / 48卷 / 02期

关键词：

D O I：

10.1016/j.devcel.2019.01.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the developing cerebellum, Sonic hedgehog (SHH) signaling is required for expansion of cerebellar granule neural progenitors, proposed to be cells-of-origin for the SHH-driven pediatric brain tumor medulloblastoma. In this issue of Developmental Cell, Chang et al. (2019) show that the transcription factor Atoh1/MATH1 regulates primary cilium formation, enabling SHH signaling.

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收藏

页码：129 / 130

页数：2

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