Non-genomic actions of aldosterone: From receptors and signals to membrane targets

被引：84

作者：

Dooley, Ruth ^{[1
]}

Harvey, Brian J. ^{[1
]}

Thomas, Warren ^{[1
]}

机构：

[1] Beaumont Hosp, Dept Mol Med, Royal Coll Surg Ireland, Educ & Res Ctr, Dublin 9, Ireland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 350卷 / 02期

基金：

爱尔兰科学基金会;

关键词：

Aldosterone; Non-genomic; Mineralocorticoid receptor; ENaC; Kidney; Protein kinase D; EPITHELIAL NA+ CHANNEL; PROTEIN-KINASE-C; VASCULAR SMOOTH-MUSCLE; HUMAN MINERALOCORTICOID RECEPTOR; COLLECTING DUCT CELLS; NITRIC-OXIDE SYNTHASE; RAT DISTAL COLON; GLUCOCORTICOID-INDUCED KINASE; PHOSPHOINOSITIDE 3-OH KINASE; COLLAGEN GENE-EXPRESSION;

D O I：

10.1016/j.mce.2011.07.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the expression of membrane targets such as the subunits of the epithelial Na+ channel, in combination with important signalling intermediates such as serum and glucocorticoid-regulated kinase-1. In addition, the rapid 'non-genomic' activation of protein kinases and secondary messenger signalling cascades has also been detected in aldosterone-sensitive tissues of the nephron, distal colon and cardiovascular system. These rapid actions are variously described as being coupled to MR or to an as yet unidentified, membrane-associated aldosterone receptor. The rapidly activated signalling cascades add a level of fine-tuning to the activity of aldosterone-responsive membrane transporters and also modulate the aldosterone-induced changes in gene expression through receptor and transcription factor phosphorylation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：223 / 234

页数：12

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