Six New Polyacetylenic Alcohols from the Marine Sponges Petrosia sp and Halichondria sp.

被引：0

作者：

Gabriel, Adeyemi Francis ^{[1
]}

Li, Zhen ^{[1
]}

Kusuda, Ryouhei ^{[1
]}

Tanaka, Chiaki ^{[1
]}

Miyamoto, Tomofumi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Nat Prod Chem, Higashi Ku, Fukuoka 8128582, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2015年 / 63卷 / 06期

关键词：

polyacetylenic alcohol; marine sponge; Petrosia sp; Halichondria sp; strongylotriol; pellynol; METABOLITES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new polyacetylenic alcohols, termed strongylotriols A and B; pellynols J, K, and L; and isopellynol A, together with three known polyacetylenic alcohols, pellynols A, B, and C were isolated from the marine sponges Petrosia sp., and Halichondria sp. collected in Okinawa, Japan. Their planer structures were determined based on 2D-NMR and mass spectrometric analysis of the degraded products by RuCl3 oxidation. The absolute stereochemistry of isolates was examined by their Mosher's esters. The strongylotriols were found to be optically pure compounds, whereas the pellynols are diastereomeric mixtures at the C-6 position. Proliferation experiments using the HeLa and K562 cell lines suggested that the essential structural units for activity are the "hexa-2,4-diyn-1,6-diol" and "pent-1-en-4-yn-3-ol" on the termini.

引用

页码：469 / 475

页数：7

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