Identification of C-type isolectins in the venom of the scorpionfish Scorpaena plumieri

被引：20
作者：
Andrich, F. [1 ,2 ]
Richardson, M. [3 ]
Naumann, G. B. [1 ,3 ]
Cordeiro, M. N. [3 ]
Santos, A. V. [4 ]
Santos, D. M. [4 ]
Oliveira, J. S. [4 ]
de Lima, M. E. [4 ]
Figueiredo, S. G. [1 ]
机构：
[1] Univ Fed Espirito Santo, Dept Ciencias Fisiol, Ctr Ciencias Saude, BR-29043900 Vitoria, ES, Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, BR-31270901 Belo Horizonte, MG, Brazil
[3] Fundacao Ezequiel Dias, Diretoria Ctr Pesquisa & Desenvolvimento, BR-30510010 Belo Horizonte, MG, Brazil
[4] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil
来源：
TOXICON | 2015年 / 95卷
关键词：
Fish venom; Scorpaena plumieri; Scorpionfish; C-type lectin; Hemagglutination; Isolectins; LECTINS; CELL;
D O I：
10.1016/j.toxicon.2015.01.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chemical analyses of the hemagglutinating fraction from Scorpaena plumieri venom revealed that it contains five components (Sp-CL 1-5) with similar chromatographic elution profiles (35-38% of acetonitrile), molecular masses (16,800-17.000 Da) and N-terminal sequences, suggesting that they are isoforms of the same protein. The amino acid sequence of Sp-CL4 was determined and shown to have homology with fish C-type lectins. These data demonstrate for the first time the presence of C-type isolectins in a scorpionfish venom. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：67 / 71
页数：5
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