Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis

被引：59

作者：

Chan, Ho-Man ^{[1
]}

Xiao, Lehui ^{[1
]}

Yeung, Kai-Ming ^{[1
]}

Ho, See-Lok ^{[1
]}

Zhao, Dan ^{[1
]}

Chan, Wing-Hong ^{[1
]}

Li, Hung-Wing ^{[1
,2
]}

机构：

[1] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

[2] Hong Kong Baptist Univ, Ctr Surface Anal & Res, Kowloon Tong, Hong Kong, Peoples R China

来源：

BIOMATERIALS | 2012年 / 33卷 / 18期

关键词：

Nanoparticle; Self-assembly; Peptide; Surface modification; GOLD NANOPARTICLES; PROTEIN FIBRILLATION; INHIBITION; BIOLOGY; SIZE; ACID;

D O I：

10.1016/j.biomaterials.2012.03.024

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric A beta(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the A beta(1-40) fibrillogenesis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4443 / 4450

页数：8

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