Antioxidants in critical illness

被引：107
作者：
Bulger, EM [1 ]
Maier, RV [1 ]
机构：
[1] Univ Washington, Harborview Med Ctr, Dept Surg, Seattle, WA 98104 USA
来源：
ARCHIVES OF SURGERY | 2001年 / 136卷 / 10期
关键词：
D O I：
10.1001/archsurg.136.10.1201
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Oxidative stress has been implicated in the manifestations of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states. This review describes the evidence for increased oxidative stress in critically ill patients and explores the data regarding antioxidant therapy for these conditions. Antioxidant therapies reviewed include N-acetylcysteine, selenium, vitamins E and C, superoxide dismutase, catalase, lazaroids, and allopurinol. We focus on the results of these interventions in animal models and human trials, when available.
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收藏
页码：1201 / 1207
页数：7
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