Repeat participation among normal healthy research volunteers - professional guinea pigs in clinical trials?

被引:41
作者
Tishler, CL
Bartholomae, S
机构
[1] Ohio State Univ, Dept Psychol, Columbus, OH 43203 USA
[2] Ohio State Univ, Dept Human Dev & Family Sci, Columbus, OH 43210 USA
关键词
D O I
10.1353/pbm.2003.0094
中图分类号
N09 [自然科学史]; B [哲学、宗教];
学科分类号
01 ; 0101 ; 010108 ; 060207 ; 060305 ; 0712 ;
摘要
The recent death of a normal healthy volunteer, as well as the increased use of normal volunteers as research subjects, has heightened the attention given to the participation of normal volunteers in clinical research. An overlooked sub-population of normal healthy volunteers are repeat, veteran volunteers. This essay discusses ethical and methodological issues associated with the use of repeat volunteers in research, along with existing guidelines regarding the use of repeat healthy volunteers, and concludes with recommendations for safeguarding repeat volunteers and ideas supporting centralized recruiting.
引用
收藏
页码:508 / 520
页数:13
相关论文
共 47 条
[1]  
*ACT COMM, 1987, ADV HLTH MIN HLTH VO
[2]  
Anderson James A., 2001, American Journal of Bioethics, V1, P67, DOI 10.1162/152651601300169194
[3]  
[Anonymous], BALTIMORE SUN 0717
[4]   Medical histories may be unreliable in screening volunteers for clinical trials [J].
Apseloff, G ;
Swayne, JK ;
Gerber, N .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1996, 60 (03) :353-356
[5]   THE IMPORTANCE OF MEASURING COTININE LEVELS TO IDENTIFY SMOKERS IN CLINICAL-TRIALS [J].
APSELOFF, G ;
ASHTON, HM ;
FRIEDMAN, H ;
GERBER, N .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1994, 56 (04) :460-462
[6]  
Beaufils F, 2001, ARCH PEDIATRIE, V8, P634
[7]  
Bielski RJ, 1997, PSYCHOPHARMACOL BULL, V33, P75
[8]   WEIGHT OF FINANCIAL REWARD IN THE DECISION BY MEDICAL-STUDENTS AND EXPERIENCED HEALTHY-VOLUNTEERS TO PARTICIPATE IN CLINICAL-TRIALS [J].
BIGORRA, J ;
BANOS, JE .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1990, 38 (05) :443-446
[9]  
BUTLER RW, 1993, AM J PSYCHIAT, V150, P1386
[10]   ATTITUDES TOWARD CLINICAL-TRIALS AMONG PATIENTS AND THE PUBLIC [J].
CASSILETH, BR ;
LUSK, EJ ;
MILLER, DS ;
HURWITZ, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1982, 248 (08) :968-970