Adipose tissue dendritic cells in steady-state

被引：13
作者：
Macdougall, Claire E. [1 ]
Longhi, M. Paula [1 ]
机构：
[1] Queen Mary Univ London, Barts & London, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
来源：
IMMUNOLOGY | 2019年 / 156卷 / 03期
关键词：
adipose tissue; dendritic cells; steady-state; tissue metabolism; PPAR-GAMMA; INSULIN-RESISTANCE; LYMPH-NODE; T-CELLS; ACTIVATION; OBESITY; RESPONSES; IMMUNITY; DIFFERENTIATION; ADIPOCYTES;
D O I：
10.1111/imm.13034
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Healthy white adipose tissue (WAT) participates in regulating systemic metabolism, whereas dysfunctional WAT plays a prominent role in the development of obesity-associated co-morbidities. Tissue-resident immune cells are important for maintaining WAT homeostasis, including conventional dendritic cells (cDCs) which are critical in the initiation and regulation of adaptive immune responses. Due to phenotypic overlap with other myeloid cells, the distinct contribution of WAT cDCs has been poorly understood. This review will discuss the contribution of cDCs in the maintenance of WAT homeostasis. In particular, the review will focus on the metabolic cross-talk between cDCs and adipocytes that regulates local immune responses during physiological conditions.
引用
收藏
页码：228 / 234
页数：7
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