7000 series Al alloy has been widely used in aeronautical structural materials because of its high strength, high stress corrosion cracking resistance and good fatigue resistance when treated by retrogression and re-ageing (RRA). Al-8Zn-2Mg-2Cu (mass fraction, %) thick plate is supposed to manufacture the aircraft wing in Chinese big plane project. Due to the non-isothermal environment in the process of heat treatment for aluminum alloy thick plate, the influence of coupling effect of non-isothermal retrogression temperature field and time on the microstructure and properties of Al-8Zn-2Mg-2Cu alloy thick plate was investigated by the non-isothermal kinetic model, mechanical properties tests, electrical conductivity test and TEM observations. The results show that, the electrical conductivity increases while the hardness and strength decrease with the non-isothermal retrogression time increasing. The optimized non-isothermal retrogression and re-ageing (NRRA) treatment makes the size distribution range of MgZn2 phase wider. Therefore, the logical matching between the dislocation cutting off mechanism and the dislocation by-passing mechanism effectively reduces the loss of hardness. Meanwhile, the electrical conductivity is significantly improved. After the treatment of 105 degrees C, 24 h (pre-ageing) and non-isothermal regression (120 min) with slow heating rate and 120 degrees C, 24 h re-ageing, the Al-8Zn-2Mg-2Cu alloy thick plate possesses an excellent comprehensive performance than those of T6 and T73 states. The tensile strength, yield strength and electrical conductivity are 620 MPa, 593 MPa and 21.1 MS/m, respectively. The NRRA treatment with slow heating rate is more suitable for the ageing treatment of thick plate.