Cardiopulmonary and sedative effects of intravenous or epidural methadone in conscious dogs

被引：4

作者：

Vieira, B. H. B. ^{[1
]}

Nishimura, L. T. ^{[1
]}

Carvalho, L. L. ^{[1
]}

Auckburally, A. ^{[2
]}

Mattos-Junior, E. ^{[1
]}

机构：

[1] Univ Franca, Vet Sci Grad Program, Franca, SP, Brazil

[2] Univ Glasgow, Coll Med Vet & Life Sci, Sch Vet Med, Dept Small Anim Clin Sci, Glasgow, Lanark, Scotland

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 2017年 / 40卷 / 06期

关键词：

cardiorespiratory; dog; extradural; opioids; sedation; PHARMACOKINETICS; ANESTHESIA; ANALGESIA; MORPHINE;

D O I：

10.1111/jvp.12416

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiopulmonary and sedative effects of intravenous or epidural methadonewere compared. Six beagles were randomly assigned to group MIV (methadone 0.5mg/kg IV + NaCl 0.9% epidurally) or MEP (methadone 0.5mg/kg epidurally + NaCl 0.9% IV). Cardiopulmonary, blood gas and sedation were assessed at time (T) 0, 15, 30, 60, 120, 240 and 480min after drug administration. Compared to T0, heart rate decreased at T15-T120 in MIV (p<.001) and T15-T240 inMEP (p<.05); mean arterial pressure was reduced at T15-T60 in MEP (p<.01); respiratory rate was higher at T15 and T30 in both groups (p<.05); pH was lower at T15-T120 in MIV (p<.01) andT15, T30 and T120 in MEP (p<.05); PaCO2 was higher at T15-T60 in MIV (p<.01) and T15, T30 and T120 in MEP (p<.01); sedation scores were higher at T15 and T30 in MIV and T15-T60 in MEP (p<.05). At T120 and T240, sedation score was higher in group MEP compared with group MIV (p<.01) In conclusion, cardiopulmonary and sedative effects of identical methadone doses are similar when administered IV or epidurally to conscious healthydogs.

引用

页码：e65 / e68

页数：4