SOCS1 downregulation in dendritic cells promotes memory T-cell responses

SOCS1-1 is crucial for control of immune cell cytokine expression, including those cytokines known to enable memory T-cell formation and homeostasis. In this study, we found that immunization with SOCS1-downregulated bone marrow-derived dendritic cells generated increased antigen-specific CD8(+) T memory cells and antigen-specific responses, as measured by ELISPOT, CTL assays, serum ELISAs, and T-cell proliferation assays. Bone marrow-derived dendritic cells in which SOCS1 was downregulated expressed increased levels of surface IL-15Ra and thymic Leukemia (TL) antigen, both of which support memory cell development. This work supports a crucial rote for SOCS1 in regulation of dendritic cell-directed generation of memory T-cell responses. (c) 2007 Elsevier Ltd. All rights reserved.