Vascular endothelium: Checkpoint for inflammation and immunity

被引:0
作者
Biedermann, BC [1 ]
机构
[1] Univ Hosp, Kantonspital Bruderholz, Dept Internal Med, CH-4101 Bruderholz, Switzerland
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2001年 / 16卷
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D O I
暂无
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Vascular endothelial cells play a threefold role in the interaction with leukocytes. First, they are gatekeepers in leukocyte recruitment to inflammatory foci and lymphocyte homing to secondary lymphoid organs. Second, they modulate leukocyte activation. Finally, they are targets of leukocyte-derived molecules, resulting either in endothelial cell activation or death.
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页码:84 / 88
页数:5
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共 18 条
  • [1] Migration of activated CD8+ T lymphocytes to sites of viral infection does not require endothelial selectins
    Bartholdy, C
    Marker, O
    Thomsen, AR
    [J]. BLOOD, 2000, 95 (04) : 1362 - 1369
  • [2] Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice
    Berlin-Rufenach, C
    Otto, F
    Mathies, M
    Westermann, J
    Owen, MJ
    Hamann, A
    Hogg, N
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (09) : 1467 - 1478
  • [3] Biedermann BC, 1999, J IMMUNOL, V162, P7022
  • [4] Biedermann BC, 1998, J IMMUNOL, V161, P4679
  • [5] Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
    Campbell, JJ
    Butcher, EC
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (03) : 336 - 341
  • [6] Colvin RB, 1997, J AM SOC NEPHROL, V8, P1930
  • [7] Cook DN, 1999, J IMMUNOL, V162, P5423
  • [8] E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells
    Hu, YY
    Kiely, JM
    Szente, BE
    Rosenzweig, A
    Gimbrone, MA
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (04) : 2142 - 2148
  • [9] Leukocyte Adhesion Deficiency Type II is a generalized defect of de novo GDP-fucose biosynthesis - Endothelial cell fucosylation is not required for neutrophil rolling on human nonlymphoid endothelium
    Karsan, A
    Cornejo, CJ
    Winn, RK
    Schwartz, BR
    Way, W
    Lannir, N
    Gershoni-Baruch, R
    Etzioni, A
    Ochs, HD
    Harlan, JM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (11) : 2438 - 2445
  • [10] Loetscher P, 2000, Adv Immunol, V74, P127