Recent advances in human iPSC-derived models of the blood-brain barrier

被引：73
|
作者：
Workman, Michael J. [1 ]
Svendsen, Clive N. [1 ]
机构：
[1] Cedars Sinai Med Ctr, Board Governors Regenerat Med Inst, Los Angeles, CA 90048 USA
来源：
FLUIDS AND BARRIERS OF THE CNS | 2020年 / 17卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Blood-brain barrier; Induced pluripotent stem cells; Human iPSC; Disease modeling; Brain microvascular endothelial cells; Organ-chip systems; MICROVASCULAR ENDOTHELIAL-CELLS; DRUG; TRANSPORTERS; DISEASE; ESTABLISHMENT; DIFFERENTIATION; ASTROCYTES; ATLAS; LINES;
D O I：
10.1186/s12987-020-00191-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The blood-brain barrier (BBB) is a critical component of the central nervous system that protects neurons and other cells of the brain parenchyma from potentially harmful substances found in peripheral circulation. Gaining a thorough understanding of the development and function of the human BBB has been hindered by a lack of relevant models given significant species differences and limited access to in vivo tissue. However, advances in induced pluripotent stem cell (iPSC) and organ-chip technologies now allow us to improve our knowledge of the human BBB in both health and disease. This review focuses on the recent progress in modeling the BBB in vitro using human iPSCs.
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页数：10
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