Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

被引：685

作者：

Atarashi, Koji ^{[1
,2
]}

Suda, Wataru ^{[1
,3
,4
]}

Luo, Chengwei ^{[5
,6
,7
]}

Kawaguchi, Takaaki ^{[1
,2
]}

Motoo, Iori ^{[2
]}

Narushima, Seiko ^{[2
]}

Kiguchi, Yuya ^{[3
]}

Yasuma, Keiko ^{[1
]}

Watanabe, Eiichiro ^{[2
]}

Tanoue, Takeshi ^{[1
,2
]}

Thaiss, Christoph A. ^{[8
]}

Sato, Mayuko ^{[9
]}

Toyooka, Kiminori ^{[9
]}

Said, Heba S. ^{[10
]}

Yamagami, Hirokazu ^{[11
]}

Rice, Scott A. ^{[12
]}

Gevers, Dirk ^{[5
]}

Johnson, Ryan C. ^{[13
]}

Segre, Julia A. ^{[13
]}

Chen, Kong ^{[14
]}

Kolls, Jay K. ^{[14
]}

Elinav, Eran ^{[8
]}

Morita, Hidetoshi ^{[15
]}

Xavier, Ramnik J. ^{[5
,6
,7
]}

Hattori, Masahira ^{[3
,4
]}

Honda, Kenya ^{[1
,2
]}

机构：

[1] Keio Univ, Dept Microbiol & Immunol, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan

[2] RIKEN, Ctr Integrat Med Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan

[3] Univ Tokyo, Grad Sch Frontier Sci, 5-1-5 Kashiwanoha, Chiba 2778561, Japan

[4] Waseda Univ, Grad Sch Adv Sci & Engn, Cooperat Major Adv Hlth Sci, Tokyo, Japan

[5] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[6] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[7] Harvard Med Sch, Boston, MA 02114 USA

[8] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[9] RIKEN, Ctr Sustainable Resource Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan

[10] Mansoura Univ, Fac Pharm, Dept Microbiol & Immunol, Mansoura 35516, Egypt

[11] Osaka City Univ, Grad Sch Med, Dept Gastroenterol, Osaka, Japan

[12] Nanyang Technol Univ, Sch Biol Sci, Singapore Ctr Environm Life Sci Engn, Singapore, Singapore

[13] NHGRI, Microbial Genom Sect, NIH, Bethesda, MD 20892 USA

[14] Univ Pittsburgh, Sch Med, Dept Pediat, Richard King Mellon Fdn Inst Pediat Res, Pittsburgh, PA 15224 USA

[15] Okayama Univ, Grad Sch Environm & Life Sci, Okayama, Japan

来源：

SCIENCE | 2017年 / 358卷 / 6361期

关键词：

ENTEROBACTER-AEROGENES; KLEBSIELLA-PNEUMONIAE; GUT MICROBIOME; CROHNS-DISEASE; DIVERSITY; INFECTION; DIET;

D O I：

10.1126/science.aan4526

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (T(H)1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host. Our findings suggest that the oral cavity may serve as a reservoir for potential intestinal pathobionts that can exacerbate intestinal disease.

引用

页码：359 / +

页数：6

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