Tacrolimus-Induced Thrombotic Microangiopathy After Orthotopic Heart Transplant: A Case Report

被引：2
作者：
Gill, Rajwinder [1 ]
Meghrajani, Vineet [2 ]
机构：
[1] Icahn Sch Med Mt Sinai Beth Israel, Internal Med, New York, NY 10003 USA
[2] Icahn Sch Med Mt Sinai Beth Israel, Cardiovasc Med, New York, NY USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 06期
关键词：
heart transplant; hemolytic uremic syndrome; hus; acquired ttp; ttp; drug induced thrombotic microangiopathy; thrombotic microangiopathy (tma); tma; tacrolimus; ditma; ECULIZUMAB; COMPLEMENT;
D O I：
10.7759/cureus.25874
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Tacrolimus (FK 506) is a calcineurin inhibitor and is commonly used as an immunosuppressant after a solid organ transplant. One of the serious adverse effects of tacrolimus is thrombotic microangiopathy (TMA) which has a high mortality rate. TMA leads to vascular thrombosis, eventually leading to ischemia of end organs. It is diagnosed clinically and based on the laboratory parameters. Early detection of TMA and prompt treatment can change the course. Drug-induced TMA has a poor prognosis as compared to idiopathic TMA. We present here the case of a 47-year-old male who developed tacrolimus-induced TMA after an orthotopic heart transplant and he was treated with the currently available treatment. He ultimately died after 40 days of hospitalization.
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