Microbial Genomics of Ancient Plagues and Outbreaks

被引:24
作者
Andam, Cheryl P. [1 ,2 ]
Worby, Colin J. [1 ]
Chang, Qiuzhi [1 ]
Campana, Michael G. [3 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[2] Univ New Hampshire, Dept Mol Cellular & Biomed Sci, Durham, NH 03824 USA
[3] Smithsonlan Conservat Biol Inst, Ctr Conservat Genom, 3001 Connecticut Ave NW, Washington, DC 20008 USA
关键词
YERSINIA-PESTIS; EBOLA-VIRUS; MYCOBACTERIUM-TUBERCULOSIS; CHOLERA OUTBREAK; INFLUENZA; ORIGIN; EPIDEMIC; PATTERNS; MEDIEVAL; ATHENS;
D O I
10.1016/j.tim.2016.08.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent use of next-generation sequencing methods to investigate historical disease outbreaks has provided us with an unprecedented ability to address important and long-standing questions in epidemiology, pathogen evolution, and human history. In this review, we present major findings that illustrate how microbial genomics has provided new insights into the nature and etiology of infectious diseases of historical importance, such as plague, tuberculosis, and leprosy. Sequenced isolates collected from archaeological remains also provide evidence for the timing of historical evolutionary events as well as geographic spread of these pathogens. Elucidating the genomic basis of virulence in historical diseases can provide relevant information on how we can effectively understand the emergence and re-emergence of infectious diseases today and in the future.
引用
收藏
页码:978 / 990
页数:13
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