Ultraviolet-Visible Light (UV-Vis)-Reversible but Fluorescence-Irreversible Chemosensor for Copper in Water and Its Application in Living Cells

被引：131

作者：

Huo, Fang-Jun ^{[2
]}

Yin, Cai-Xia ^{[1
]}

Yang, Yu-Tao ^{[1
]}

Su, Jing ^{[1
]}

Chao, Jian-Bin ^{[2
]}

Liu, Dian-Sheng ^{[1
]}

机构：

[1] Shanxi Univ, Key Lab Chem Biol & Mol Engn, Minist Educ, Inst Mol Sci, Taiyuan 030006, Peoples R China

[2] Shanxi Univ, Res Inst Appl Cheemistry, Taiyuan 030006, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2012年 / 84卷 / 05期

基金：

山西省青年科学基金; 中国国家自然科学基金;

关键词：

AQUEOUS-SOLUTION; ANION RECEPTORS; COLORIMETRIC SENSORS; NITRIC-OXIDE; RECOGNITION; DERIVATIVES; PROBE; CU2+; IONS; ACID;

D O I：

10.1021/ac202734m

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An ultraviolet visible light (UV-Vis)-reversible but fluorescence-irreversible chemosensor was developed for the detection of copper. Coordination between the probe, 2-pyridylaldehyde fluorescein hydrazone (FHP), and Cu2+ gave a reversible UV-Vis response, Storage of the probe Cu complex resulted in hydrolytic cleavage of the N=C bond, which released the fluorophore (ring-opened fluorescein hydrazine) and gave irreversible fluorescence. Thus, FHP becomes a multifunctional chemosensor, and its reversibility can be controlled by the reaction time. Cu2+ in living cells could be detected using FHP and general fluorescence methods.

引用

页码：2219 / 2223

页数：5

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