Effects of Ulinastatin, a Urinary Trypsin Inhibitor, on Synaptic Plasticity and Spatial Memory in a Rat Model of Cerebral Ischemia/Reperfusion Injury

被引：1
作者：
Cao, Li-Jun [1 ,2 ]
Wang, Jin [3 ]
Hao, Pan-Pan [1 ,2 ]
Sun, Chun-Li [1 ,2 ]
Chen, Yu-Guo [1 ,2 ]
机构：
[1] Shandong Univ, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[2] Shandong Univ, Chinese Minist Publ Hlth, Qilu Hosp, Jinan 250012, Shandong, Peoples R China
[3] Shandong Univ, Dept Pharmacol, Sch Med, Jinan 250012, Shandong, Peoples R China
来源：
CHINESE JOURNAL OF PHYSIOLOGY | 2011年 / 54卷 / 06期
关键词：
ulinastatin; cerebral ischemia-reperfusion injury; synaptophysin; S100; beta; Morris water maze; LONG-TERM POTENTIATION; ARTERY OCCLUSION; STROKE; SYNAPTOPHYSIN; REPERFUSION; HIPPOCAMPUS; EXPRESSION; ISCHEMIA; VESICLES; NEURONS;
D O I：
10.4077/CJP.2011.BAA058
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Established therapies for cerebral ischemia-reperfusion injury are currently limited. The urinary trypsin inhibitor ulinastatin (UTI) is considered cytoprotective against ischemia-reperfusion injury in internal organs through its anti-inflammatory activity. We aimed to investigate the neuroprotective effects of UTI on learning and memory of rats after cerebral ischemia-reperfusion injury. Rats were treated with UTI at 10,000 U/kg body weight, then underwent ischemia and reperfusion by the middle cerebral arterial occlusion (MCAO) method. At various times after the onset of reperfusion, we evaluated neurologic impairment scores. Brain sections underwent immunohistochemical staining for synaptophysin and calcium-binding protein s100 beta. Other rats underwent the Morris water maze test to determine the effects of UTI on learning and memory. Spatial reference learning and memory were improved with UTI treatment by down-regulating S100 beta-positive cells and preventing the loss of neural cells. Thus, UTI has a neuroprotective role on synaptic plasticity and spatial memory with cerebral ischemia-reperfusion injury in rats.
引用
收藏
页码：435 / 442
页数：8
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