B lymphocytes as effector cells in the immunotherapy of cancer

被引：22

作者：

Namm, Jukes P. ^{[1
,2
]}

Li, Qiao ^{[1
]}

Lao, Xiangming ^{[1
,3
,4
]}

Lubman, David M. ^{[1
]}

He, Jintang ^{[1
]}

Liu, Yashu ^{[1
]}

Zhu, Jianhui ^{[1
]}

Wei, Shuang ^{[1
]}

Chang, Alfred E. ^{[1
]}

机构：

[1] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[2] Loma Linda Univ, Dept Surg, Loma Linda, CA 92350 USA

[3] Sun Yat Sen Univ, Ctr Canc, Guangzhou 510275, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, State Key Lab Oncol So China, Guangzhou 510275, Guangdong, Peoples R China

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2012年 / 105卷 / 04期

关键词：

B cells; antibody; adoptive immunotherapy; tumor antigen; ANTIGEN-PRESENTING CELLS; ANTI-CD3; MONOCLONAL-ANTIBODY; X-LINKED AGAMMAGLOBULINEMIA; T-CELLS; IN-VIVO; TUMOR-REGRESSION; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR IMMUNITY; DEPRIVED MICE; LYMPH-NODES;

D O I：

10.1002/jso.22093

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the years, the role of B cells in the host immune response to malignancy has been overshadowed by our focus on T cells. Nevertheless, B cells play important roles as antigen-presenting cells and in the production of antibodies. Furthermore, B cells can function as effector cells that mediate tumor destruction on their own. This review will highlight the various functions of B cells that are involved in the host response to tumor. J. Surg. Oncol. 2012;105:431435. (c) 2011 Wiley Periodicals, Inc.

引用

页码：431 / 435

页数：5

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