Brain metabolism as a modulator of autophagy in neurodegeneration

被引：20
作者：
Lim, Yun [1 ]
Cho, Hanchae [1 ]
Kim, Eun-Kyoung [1 ,2 ]
机构：
[1] Daegu Gyeongbuk Inst Sci & Technol, Dept Brain & Cognit Sci, 333 Techno Jungang Daero, Daegu 42988, South Korea
[2] Daegu Gyeongbuk Inst Sci & Technol, Neurometab Res Ctr, 333 Techno Jungang Daero, Daegu 42988, South Korea
来源：
BRAIN RESEARCH | 2016年 / 1649卷
基金：
新加坡国家研究基金会;
关键词：
Brain; Autophagy; Metabolism; Neurodegenerative disease; Hormone; Nutrient; TRANSGENIC MOUSE MODEL; FREE FATTY-ACIDS; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; PARKINSONS-DISEASE; TAU PHOSPHORYLATION; GLUCOSE DEPRIVATION; GLYCOGEN-AUTOPHAGY; OXIDATIVE STRESS; MAMMALIAN TARGET;
D O I：
10.1016/j.brainres.2016.02.049
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases are accompanied by altered metabolism and autophagy in the brain. In this review, we discuss how hormones and nutrients regulate autophagy in the brain and affect neurodegeneration. This article is part of a Special Issue entitled SI:Autophagy. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：158 / 165
页数：8
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