A new definition of solubilization power of a cosolvent

被引：15

作者：

Jouyban, A. ^{[1
,2
]}

Fakhree, M. A. A. ^{[3
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz 51664, Iran

[3] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz 51664, Iran

来源：

PHARMAZIE | 2008年 / 63卷 / 04期

关键词：

D O I：

10.1691/ph.2008.7288

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubilization power of a cosolvent is defined based on the maximum solubility of a solute in the water-cosolvent mixtures (X-m,X-max) and the corresponding solvent composition (f(c,max)) predicted by trained versions of the Jouyban-Acree model. The applicability of the proposed definition was checked using solubility data of three cosolvent systems where the solubilization power was ordered as: dioxane > ethanol > polyethylene glycol 400. Using this definition, one could select the most appropriate cosolvent for solubilization of a poorly water soluble drug. There are linear relationships between the solubilization power of a cosolvent and the solute's logarithm of partition coefficients.

引用

页码：317 / 319

页数：3

共 13 条

[1] MATHEMATICAL REPRESENTATION OF THERMODYNAMIC PROPERTIES .2. DERIVATION OF THE COMBINED NEARLY IDEAL BINARY SOLVENT (NIBS) REDLICH-KISTER MATHEMATICAL REPRESENTATION FROM A 2-BODY AND 3-BODY INTERACTIONAL MIXING MODEL [J].