MR1-restricted mucosal-associated invariant T cells and their activation during infectious diseases

被引：61

作者：

Howson, Lauren J. ^{[1
]}

Salio, Mariolina ^{[1
]}

Cerundolo, Vincenzo ^{[1
]}

机构：

[1] Univ Oxford, MRC Human Immunol Unit, Weatherall Inst Mol Med, Oxford, England

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

基金：

英国医学研究理事会;

关键词：

MAIT cells; infection; MR1; bacteria; vitamins; MR1 ANTIGEN PRESENTATION; MAIT CELLS; HIV-INFECTION; RECEPTOR HETEROGENEITY; BACTERIAL-INFECTION; MULTIPLE-SCLEROSIS; IMMUNE-RESPONSES; ALPHA-CHAIN; EXPRESSION; TCR;

D O I：

10.3389/fimmu.2015.00303

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from Escherichia coli to Mycobacterium tuberculosis and BCG. MAIT cells have been described as innate sensors of infection as they accumulate early in infected tissues. MAIT cells maintain an activated phenotype throughout the course of infections, secrete inflammatory cytokines, and have the potential to directly kill infected cells, playing an important role in shaping the host response. In this review, we will discuss the current knowledge regarding the molecular mechanisms that underline MAIT cells activation in sterile and non-sterile inflammatory conditions.

引用

页数：9

共 63 条

[1] CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis [J].

Annibali, Viviana ;

Ristori, Giovanni ;

Angelini, Daniela F. ;

Serafini, Barbara ;

Mechelli, Rosella ;

Cannoni, Stefania ;

Romano, Silvia ;

Paolillo, Andrea ;

Abderrahim, Hadi ;

Diamantini, Adamo ;

Borsellino, Giovanna ;

Aloisi, Francesca ;

Battistini, Luca ;

Salvetti, Marco .

BRAIN, 2011, 134 :542-554

[2] Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties [J].

Billerbeck, Eva ;

Kang, Yu-Hoi ;

Walker, Lucy ;

Lockstone, Helen ;

Grafmueller, Stefanie ;

Fleming, Vicki ;

Flint, Jonathan ;

Willberg, Chris B. ;

Bengsch, Bertram ;

Seigel, Bianca ;

Ramamurthy, Narayan ;

Zitzmann, Nicole ;

Barnes, Eleanor J. ;

Thevanayagam, Jonarthan ;

Bhagwanani, Anisha ;

Leslie, Alasdair ;

Oo, Ye H. ;

Kollnberger, Simon ;

Bowness, Paul ;

Drognitz, Oliver ;

Adams, David H. ;

Blum, Hubert E. ;

Thimme, Robert ;

Klenerman, Paul .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) :3006-3011

[3] Microbial translocation is a cause of systemic immune activation in chronic HIV infection [J].

Brenchley, Jason M. ;

Price, David A. ;

Schacker, Timothy W. ;

Asher, Tedi E. ;

Silvestri, Guido ;

Rao, Srinivas ;

Kazzaz, Zachary ;

Bornstein, Ethan ;

Lambotte, Olivier ;

Altmann, Daniel ;

Blazar, Bruce R. ;

Rodriguez, Benigno ;

Teixeira-Johnson, Leia ;

Landay, Alan ;

Martin, Jeffrey N. ;

Hecht, Frederick M. ;

Picker, Louis J. ;

Lederman, Michael M. ;

Deeks, Steven G. ;

Douek, Daniel C. .

NATURE MEDICINE, 2006, 12 (12) :1365-1371

[4] Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus [J].

Cho, Young-Nan ;

Kee, Seung-Jung ;

Kim, Tae-Jong ;

Jin, Hye Mi ;

Kim, Moon-Ju ;

Jung, Hyun-Ju ;

Park, Ki-Jeong ;

Lee, Sung-Ji ;

Lee, Shin-Seok ;

Kwon, Yong-Soo ;

Kee, Hae Jin ;

Kim, Nacksung ;

Park, Yong-Wook .

JOURNAL OF IMMUNOLOGY, 2014, 193 (08) :3891-3901

[5] Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection [J].

Chua, Wei-Jen ;

Truscott, Steven M. ;

Eickhoff, Christopher S. ;

Blazevic, Azra ;

Hoft, Daniel F. ;

Hansen, Ted H. .

INFECTION AND IMMUNITY, 2012, 80 (09) :3256-3267

[6] T-cell activation by transitory neo-antigens derived from distinct microbial pathways [J].

Corbett, Alexandra J. ;

Eckle, Sidonia B. G. ;

Birkinshaw, Richard W. ;

Liu, Ligong ;

Patel, Onisha ;

Mahony, Jennifer ;

Chen, Zhenjun ;

Reantragoon, Rangsima ;

Meehan, Bronwyn ;

Cao, Hanwei ;

Williamson, Nicholas A. ;

Strugnell, Richard A. ;

Van Sinderen, Douwe ;

Mak, Jeffrey Y. W. ;

Fairlie, David P. ;

Kjer-Nielsen, Lars ;

Rossjohn, Jamie ;

McCluskey, James .

NATURE, 2014, 509 (7500) :361-+

[7] Early and nonreversible decrease of CD161++/MAIT cells in HIV infection [J].

Cosgrove, Cormac ;

Ussher, James E. ;

Rauch, Andri ;

Gaertner, Kathleen ;

Kurioka, Ayako ;

Huehn, Michael H. ;

Adelmann, Krista ;

Kang, Yu-Hoi ;

Fergusson, Joannah R. ;

Simmonds, Peter ;

Goulder, Philip ;

Hansen, Ted H. ;

Fox, Julie ;

Guenthard, Huldrych F. ;

Khanna, Nina ;

Powrie, Fiona ;

Steel, Alan ;

Gazzard, Brian ;

Phillips, Rodney E. ;

Frater, John ;

Uhlig, Holm ;

Klenerman, Paul .

BLOOD, 2013, 121 (06) :951-961

[8] Bacterial invasion: The paradigms of enteroinvasive pathogens [J].

Cossart, P ;

Sansonetti, PJ .

SCIENCE, 2004, 304 (5668) :242-248

[9] Invariant Vα19i T cells regulate autoimmune inflammation [J].

Croxford, J. Ludovic ;

Miyake, Sachiko ;

Huang, Yi-Ying ;

Shimamura, Michio ;

Yamamura, Takashi .

NATURE IMMUNOLOGY, 2006, 7 (09) :987-994

[10] Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease [J].

Dunne, Margaret R. ;

Elliott, Louise ;

Hussey, Seamus ;

Mahmud, Nasir ;

Kelly, Jacinta ;

Doherty, Derek G. ;

Feighery, Conleth F. .

PLOS ONE, 2013, 8 (10)

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