Transoral robotic surgery for the identification of unknown primary head and neck squamous cell carcinomas: Its effect on the wait and the weight

被引：7

作者：

Alzahrani, Faisal ^{[1
,2
]}

Sahovaler, Axel ^{[1
]}

Mundi, Neil ^{[3
]}

Rammal, Almoaidbellah ^{[4
]}

Fnais, Naif ^{[1
,2
]}

MacNeil, S. Danielle ^{[1
]}

Mendez, Adrian ^{[1
]}

Yoo, John ^{[1
]}

Fung, Kevin ^{[1
]}

Laxague, Francisco ^{[1
]}

Warner, Andrew ^{[5
]}

Palma, David A. ^{[5
]}

Nichols, Anthony ^{[1
]}

机构：

[1] Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON, Canada

[2] King Saud Univ, Dept Otolaryngol Head & Neck Surg, Riyadh, Saudi Arabia

[3] Southern Illinois Univ, Dept Otolaryngol, Springfield, IL USA

[4] King AbdulAziz Univ, Dept Otolaryngol Head & Neck Surg, Jeddah, Saudi Arabia

[5] Western Univ, Dept Radiat Oncol, London, ON, Canada

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2022年 / 44卷 / 05期

关键词：

carcinoma of unknown primary; complications; transoral robotic surgery; treatment delay; weight; LYMPH-NODE METASTASES; FDG-PET/CT; PRIMARY TUMORS; PRIMARY SITE; MANAGEMENT;

D O I：

10.1002/hed.27023

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background Neck carcinoma of unknown primary (CUP) is a frequent scenario. Transoral robotic mucosectomies (TORM) of pharynx have increased rate of primary identification, but come with cost of treatment delay. Methods We reviewed patients who underwent CUP protocol from 2014 to 2020. Patients with cervical nodes carcinoma and failure to localize a primary source were classified as CUP. We determined primary identification rate and postoperative complications. Results We included 65 patients underwent TORM. Surgical approach consisted of lingual and/or palatine tonsillectomies. The primary detection rate was 49.2%. Average weight reduction was 2.5 +/- 4.3 kg. The average number of days from consultation to definitive treatment was 52.2 +/- 18.3. Conclusion A systematic approach to patients with CUP showed a promising primary identification rate compared to panendoscopy alone. TORM carries a small risk of complications. The benefits of primary identification must be weighed with the morbidity and delay to definitive treatment.

引用

页码：1206 / 1212

页数：7

共 25 条

[1]

[Anonymous], 2021, National Comprehensive Cancer Network clinical practice guidelines in oncology, head and neck cancers

[2] Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers [J].

Chaturvedi, Anil K. ;

Anderson, William F. ;

Lortet-Tieulent, Joannie ;

Curado, Maria Paula ;

Ferlay, Jacques ;

Franceschi, Silvia ;

Rosenberg, Philip S. ;

Bray, Freddie ;

Gillison, Maura L. .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (36) :4550-4559

[3] Cervical lymph node metastases of squamous cell carcinoma of unknown origin: the diagnostic value of FDG PET/CT and clinical outcome [J].

Dale, Einar ;

Moan, Jon M. ;

Osnes, Terje A. ;

Bogsrud, Trond V. .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2017, 274 (02) :1015-1019

[4] Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis [J].

Di Maio, Pasquale ;

Iocca, Oreste ;

De Virgilio, Armando ;

Ferreli, Fabio ;

Cristalli, Giovanni ;

Pellini, Raul ;

Golusinski, Pawel ;

Ricci, Giampietro ;

Spriano, Giuseppe .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2019, 41 (04) :1112-1121

[5] Functional and Quality-of-Life Outcomes of Transoral Robotic Surgery for Carcinoma of Unknown Primary [J].

Durmus, Kasim ;

Patwa, Hafiz S. ;

Gokozan, Hamza N. ;

Kucur, Cuneyt ;

Teknos, Theodoros N. ;

Agrawal, Amit ;

Old, Matthew O. ;

Ozer, Enver .

LARYNGOSCOPE, 2014, 124 (09) :2089-2095

[6] The role of transoral robotic surgery, transoral laser microsurgery, and lingual tonsillectomy in the identification of head and neck squamous cell carcinoma of unknown primary origin: a systematic review [J].

Fu, Terence S. ;

Foreman, Andrew ;

Goldstein, David P. ;

de Almeida, John R. .

JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2016, 45

[7] Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status [J].

Geltzeiler, Mathew ;

Doerfler, Sean ;

Turner, Meghan ;

Albergotti, William Greer ;

Kubik, Mark ;

Kim, Seungwon ;

Ferris, Robert ;

Duvvuri, Umamaheswar .

ORAL ONCOLOGY, 2017, 66 :9-13

[8] Association of Treatment Delays With Survival for PatientsWith Head and Neck Cancer A Systematic Review [J].

Graboyes, Evan M. ;

Kompelli, Anvesh R. ;

Neskey, David M. ;

Brennan, Emily ;

Shaun Nguyen ;

Sterba, Katherine R. ;

Warren, GrahamW. ;

Hughes-Halbert, Chanita ;

Nussenbaum, Brian ;

Day, Terry A. .

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2019, 145 (02) :166-177

[9] Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries [J].

Hatten, Kyle M. ;

O'Malley, Bertw., Jr. ;

Bur, Andres M. ;

Patel, Mihir R. ;

Rassekh, Christopher H. ;

Newman, Jason G. ;

Cannady, Steven B. ;

Chalian, Ara A. ;

Hodnett, Benjamin L. ;

Lin, Alexander ;

Lukens, John N. ;

Cohen, Roger B. ;

Bauml, Joshua M. ;

Montone, Kathleen T. ;

Livolsi, Virginia A. ;

Weinstein, Gregory S. .

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2017, 143 (03) :267-273

[10] Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later [J].

Huang, Shao Hui ;

Waldron, John ;

Bratman, Scott V. ;

Su, Jie ;

Kim, John ;

Bayley, Andrew ;

Cho, John ;

Giuliani, Meredith ;

Hope, Andrew ;

Ringash, Jolie ;

Hansen, Aaron ;

de Almeida, John R. ;

Goldstein, David ;

Perez-Ordonez, Bayardo ;

Weinreb, Ilan ;

Tong, Li ;

Xu, Wei ;

O'Sullivan, Brian .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 98 (01) :159-169

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